Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome
The amygdala and hippocampus undergo rapid development in early life. The relative contribution of genetic and environmental factors to the establishment of their developmental trajectories has yet to be examined. We performed imaging on neonates and examined how the observed variation in volume and...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/147061 |
| _version_ | 1811681825626521600 |
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| author | Ong, Mei-Lyn Tuan, Ta A. Poh, Joann Teh, Ai L. Chen, Li Pan, Hong MacIsaac, Julia L. Kobor, Michael S. Chong, Yap S. Kwek, Kenneth Saw, Seang M. Godfrey, Keith M. Gluckman, Peter D. Fortier, Marielle V. Karnani, Neerja Meaney, Michael J. Qiu, Anqi Holbrook, Joanna D. |
| author2 | School of Computer Science and Engineering |
| author_facet | School of Computer Science and Engineering Ong, Mei-Lyn Tuan, Ta A. Poh, Joann Teh, Ai L. Chen, Li Pan, Hong MacIsaac, Julia L. Kobor, Michael S. Chong, Yap S. Kwek, Kenneth Saw, Seang M. Godfrey, Keith M. Gluckman, Peter D. Fortier, Marielle V. Karnani, Neerja Meaney, Michael J. Qiu, Anqi Holbrook, Joanna D. |
| author_sort | Ong, Mei-Lyn |
| collection | NTU |
| description | The amygdala and hippocampus undergo rapid development in early life. The relative contribution of genetic and environmental factors to the establishment of their developmental trajectories has yet to be examined. We performed imaging on neonates and examined how the observed variation in volume and microstructure of the amygdala and hippocampus varied by genotype, and compared with prenatal maternal mental health and socioeconomic status. Gene × Environment models outcompeted models containing genotype or environment only to best explain the majority of measures but some, especially of the amygdaloid microstructure, were best explained by genotype only. Models including DNA methylation measured in the neonate umbilical cords outcompeted the Gene and Gene × Environment models for the majority of amygdaloid measures and minority of hippocampal measures. This study identified brain region-specific gene networks associated with individual differences in fetal brain development. In particular, genetic and epigenetic variation within CUX1 was highlighted. |
| first_indexed | 2024-10-01T03:47:06Z |
| format | Journal Article |
| id | ntu-10356/147061 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:47:06Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1470612021-03-19T08:12:48Z Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome Ong, Mei-Lyn Tuan, Ta A. Poh, Joann Teh, Ai L. Chen, Li Pan, Hong MacIsaac, Julia L. Kobor, Michael S. Chong, Yap S. Kwek, Kenneth Saw, Seang M. Godfrey, Keith M. Gluckman, Peter D. Fortier, Marielle V. Karnani, Neerja Meaney, Michael J. Qiu, Anqi Holbrook, Joanna D. School of Computer Science and Engineering Science::Biological sciences Developmental Trajectory Diffusion Tensor Imaging The amygdala and hippocampus undergo rapid development in early life. The relative contribution of genetic and environmental factors to the establishment of their developmental trajectories has yet to be examined. We performed imaging on neonates and examined how the observed variation in volume and microstructure of the amygdala and hippocampus varied by genotype, and compared with prenatal maternal mental health and socioeconomic status. Gene × Environment models outcompeted models containing genotype or environment only to best explain the majority of measures but some, especially of the amygdaloid microstructure, were best explained by genotype only. Models including DNA methylation measured in the neonate umbilical cords outcompeted the Gene and Gene × Environment models for the majority of amygdaloid measures and minority of hippocampal measures. This study identified brain region-specific gene networks associated with individual differences in fetal brain development. In particular, genetic and epigenetic variation within CUX1 was highlighted. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Medical Research Council (NMRC) National Medical Research Council, Grant/Award Numbers: NMRC/TCR/004-NUS/2008,NMRC/TCR/012-NUHS/2014; NUS Instituteof Data Science, Singapore; Singapore Ministryof Education; Agency for Science Technologyand Research (ASTAR); Singapore Institute forClinical Sciences; Singapore National ResearchFoundation 2021-03-19T08:12:48Z 2021-03-19T08:12:48Z 2019 Journal Article Ong, M., Tuan, T. A., Poh, J., Teh, A. L., Chen, L., Pan, H., MacIsaac, J. L., Kobor, M. S., Chong, Y. S., Kwek, K., Saw, S. M., Godfrey, K. M., Gluckman, P. D., Fortier, M. V., Karnani, N., Meaney, M. J., Qiu, A. & Holbrook, J. D. (2019). Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome. Genes, Brain and Behavior, 18(7), 12576--. https://dx.doi.org/10.1111/gbb.12576 1601-1848 0000-0002-0215-6338 0000-0003-1791-6894 https://hdl.handle.net/10356/147061 10.1111/gbb.12576 31020763 2-s2.0-85066052849 7 18 12576- en NMRC/TCR/004-NUS/2008 NMRC/TCR/012-NUHS/2014 Genes, Brain and Behavior © 2019 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society. All rights reserved. |
| spellingShingle | Science::Biological sciences Developmental Trajectory Diffusion Tensor Imaging Ong, Mei-Lyn Tuan, Ta A. Poh, Joann Teh, Ai L. Chen, Li Pan, Hong MacIsaac, Julia L. Kobor, Michael S. Chong, Yap S. Kwek, Kenneth Saw, Seang M. Godfrey, Keith M. Gluckman, Peter D. Fortier, Marielle V. Karnani, Neerja Meaney, Michael J. Qiu, Anqi Holbrook, Joanna D. Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title | Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title_full | Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title_fullStr | Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title_full_unstemmed | Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title_short | Neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment, and reflected in the neonatal DNA methylome |
| title_sort | neonatal amygdalae and hippocampi are influenced by genotype and prenatal environment and reflected in the neonatal dna methylome |
| topic | Science::Biological sciences Developmental Trajectory Diffusion Tensor Imaging |
| url | https://hdl.handle.net/10356/147061 |
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