Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

Pharmaceutical modulation of the proteolytic profile of Transforming Growth Factor Beta induced protein (TGFBIp) offers a new avenue for treatment of TGFBI-corneal dystrophy

Corneal dystrophies are a group of genetically inherited disorders with mutations in the TGFBI gene affecting the Bowman's membrane and the corneal stroma. The mutant TGFBIp is highly aggregation-prone and is deposited in the cornea. Depending on the type of mutation the protein deposits may va...

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Bibliographic Details
Main Authors: Venkatraman, Anandalakshmi, Duong-Thi, Minh-Dao, Pervushin, Konstantin, Ohlson, Sten, Mehta, Jodhbir Singh
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Corneal Dystrophy
Weak Affinity Chromatography
Online Access:https://hdl.handle.net/10356/147334

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