Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation
Indium phosphide/zinc sulfate (InP/ZnS) quantum dots (QDs) are presumed to be less hazardous than those that contain cadmium. However, the toxicological profile has not been established. The present study investigated the acute toxicity of InP/ZnS QDs with different surface modifications (COOH, NH2,...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/147367 |
| _version_ | 1826126775822843904 |
|---|---|
| author | Lin, Guimiao Chen, Ting Pan, Yongning Yang, Zhiwen Li, Li Yong, Ken-Tye Wang, Xiaomei Wang, Jie Chen, Yajing Jiang, Wenxiao Weng, Shuting Huang, Xiaorui Kuang, Jiajie Xu, Gaixia |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Lin, Guimiao Chen, Ting Pan, Yongning Yang, Zhiwen Li, Li Yong, Ken-Tye Wang, Xiaomei Wang, Jie Chen, Yajing Jiang, Wenxiao Weng, Shuting Huang, Xiaorui Kuang, Jiajie Xu, Gaixia |
| author_sort | Lin, Guimiao |
| collection | NTU |
| description | Indium phosphide/zinc sulfate (InP/ZnS) quantum dots (QDs) are presumed to be less hazardous than those that contain cadmium. However, the toxicological profile has not been established. The present study investigated the acute toxicity of InP/ZnS QDs with different surface modifications (COOH, NH2, and OH) in mice after pulmonary aerosol inhalation. InP/ZnS QDs were able to pass through the blood-gas barrier and enter the circulation, and subsequently accumulated in major organs. No obvious changes were observed in the body weight or major organ coefficients. Red blood cell counts and platelet-related indicators were in the normal range, but the proportion of white blood cells was altered. The InP/ZnS QDs caused varying degrees of changes in some serum markers, but no histopathological abnormalities related to InP/ZnS QDs treatment was observed in major organs except that hyperemia in alveolar septa was found in lung sections. These results suggested that the effects of respiratory exposure to InP/ZnS QDs on the lungs need to be fully considered in future biomedical application although the overall toxicity of quantum dots is relatively low. |
| first_indexed | 2024-10-01T06:57:52Z |
| format | Journal Article |
| id | ntu-10356/147367 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:57:52Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1473672021-03-31T03:59:20Z Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation Lin, Guimiao Chen, Ting Pan, Yongning Yang, Zhiwen Li, Li Yong, Ken-Tye Wang, Xiaomei Wang, Jie Chen, Yajing Jiang, Wenxiao Weng, Shuting Huang, Xiaorui Kuang, Jiajie Xu, Gaixia School of Electrical and Electronic Engineering Engineering::Nanotechnology InP/ZnS Quantum Dot Biodistribution Indium phosphide/zinc sulfate (InP/ZnS) quantum dots (QDs) are presumed to be less hazardous than those that contain cadmium. However, the toxicological profile has not been established. The present study investigated the acute toxicity of InP/ZnS QDs with different surface modifications (COOH, NH2, and OH) in mice after pulmonary aerosol inhalation. InP/ZnS QDs were able to pass through the blood-gas barrier and enter the circulation, and subsequently accumulated in major organs. No obvious changes were observed in the body weight or major organ coefficients. Red blood cell counts and platelet-related indicators were in the normal range, but the proportion of white blood cells was altered. The InP/ZnS QDs caused varying degrees of changes in some serum markers, but no histopathological abnormalities related to InP/ZnS QDs treatment was observed in major organs except that hyperemia in alveolar septa was found in lung sections. These results suggested that the effects of respiratory exposure to InP/ZnS QDs on the lungs need to be fully considered in future biomedical application although the overall toxicity of quantum dots is relatively low. Published version 2021-03-31T03:59:20Z 2021-03-31T03:59:20Z 2020 Journal Article Lin, G., Chen, T., Pan, Y., Yang, Z., Li, L., Yong, K., Wang, X., Wang, J., Chen, Y., Jiang, W., Weng, S., Huang, X., Kuang, J. & Xu, G. (2020). Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation. Nanotheranostics, 4(3), 173-183. https://dx.doi.org/10.7150/ntno.42786 2206-7418 https://hdl.handle.net/10356/147367 10.7150/ntno.42786 32483522 3 4 173 183 en Nanotheranostics © 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. application/pdf |
| spellingShingle | Engineering::Nanotechnology InP/ZnS Quantum Dot Biodistribution Lin, Guimiao Chen, Ting Pan, Yongning Yang, Zhiwen Li, Li Yong, Ken-Tye Wang, Xiaomei Wang, Jie Chen, Yajing Jiang, Wenxiao Weng, Shuting Huang, Xiaorui Kuang, Jiajie Xu, Gaixia Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title | Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title_full | Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title_fullStr | Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title_full_unstemmed | Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title_short | Biodistribution and acute toxicity of cadmium-free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| title_sort | biodistribution and acute toxicity of cadmium free quantum dots with different surface functional groups in mice following intratracheal inhalation |
| topic | Engineering::Nanotechnology InP/ZnS Quantum Dot Biodistribution |
| url | https://hdl.handle.net/10356/147367 |
| work_keys_str_mv | AT linguimiao biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT chenting biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT panyongning biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT yangzhiwen biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT lili biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT yongkentye biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT wangxiaomei biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT wangjie biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT chenyajing biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT jiangwenxiao biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT wengshuting biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT huangxiaorui biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT kuangjiajie biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation AT xugaixia biodistributionandacutetoxicityofcadmiumfreequantumdotswithdifferentsurfacefunctionalgroupsinmicefollowingintratrachealinhalation |