Catalytic properties of human apurinic/apyrimidinic endonuclease 1 (APE1) and development of biosensors of APE1 in living cells
Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme involved in the DNA base excision repair pathway and responsible for restoring mutagenic and cytotoxic abasic lesions throughout cell cycles. APE1 will cleave the 5’ end phosphodiester backbone right next to the generated apurinic/ap...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/147410 |