Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases
Obesity is a serious epidemic health problem that can cause many other diseases including type 2 diabetes and cardiovascular diseases. Current approaches to combat obesity suffer from low effectiveness and adverse side effects. Here, a new self-administrable and minimally invasive transdermal drug d...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/147527 |
| _version_ | 1824454194888704000 |
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| author | Than, Aung Duong, Phan Khanh Zan, Ping Liu, Junjie Leow, Melvin Khee-Shing Chen, Peng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Than, Aung Duong, Phan Khanh Zan, Ping Liu, Junjie Leow, Melvin Khee-Shing Chen, Peng |
| author_sort | Than, Aung |
| collection | NTU |
| description | Obesity is a serious epidemic health problem that can cause many other diseases including type 2 diabetes and cardiovascular diseases. Current approaches to combat obesity suffer from low effectiveness and adverse side effects. Here, a new self-administrable and minimally invasive transdermal drug delivery strategy for home-based long-term treatment of obesity and other diseases is developed. Specifically, ultrathin, core-shelled, and lance-shaped polymeric drug reservoirs (micro-lances [MLs]) are readily fabricated by a thermal pressing molding method and totally implanted into subcutaneous fat by lancing through the skin. Using a diet-induced obese mouse model, it is shown that the development of obesity and associated metabolic disorders is effectively inhibited by applying therapeutic core-shelled MLs once every 2 weeks. The outstanding therapeutic effects are attributable to highly localized and biphasic drug release, as well as combination therapy based on browning transformation of white fat and enhanced insulin sensitivity. |
| first_indexed | 2025-02-19T03:18:27Z |
| format | Journal Article |
| id | ntu-10356/147527 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:18:27Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1475272023-12-29T06:53:30Z Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases Than, Aung Duong, Phan Khanh Zan, Ping Liu, Junjie Leow, Melvin Khee-Shing Chen, Peng School of Chemical and Biomedical Engineering Innovative Centre for Flexible Devices Engineering Transdermal Drug Delivery Controlled Release Obesity is a serious epidemic health problem that can cause many other diseases including type 2 diabetes and cardiovascular diseases. Current approaches to combat obesity suffer from low effectiveness and adverse side effects. Here, a new self-administrable and minimally invasive transdermal drug delivery strategy for home-based long-term treatment of obesity and other diseases is developed. Specifically, ultrathin, core-shelled, and lance-shaped polymeric drug reservoirs (micro-lances [MLs]) are readily fabricated by a thermal pressing molding method and totally implanted into subcutaneous fat by lancing through the skin. Using a diet-induced obese mouse model, it is shown that the development of obesity and associated metabolic disorders is effectively inhibited by applying therapeutic core-shelled MLs once every 2 weeks. The outstanding therapeutic effects are attributable to highly localized and biphasic drug release, as well as combination therapy based on browning transformation of white fat and enhanced insulin sensitivity. Ministry of Education (MOE) This research was supported by Singapore Ministry of Education under its AcRF tier-1 grant (RG52/17) and AcRF tier-2 grant (MOE2017-T2-2-005). 2021-04-06T02:00:45Z 2021-04-06T02:00:45Z 2020 Journal Article Than, A., Duong, P. K., Zan, P., Liu, J., Leow, M. K. & Chen, P. (2020). Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases. Small, 16(31), e2002872-. https://dx.doi.org/10.1002/smll.202002872 1613-6829 0000-0003-1558-7310 0000-0003-3730-1846 https://hdl.handle.net/10356/147527 10.1002/smll.202002872 32603020 2-s2.0-85087210856 31 16 e2002872 en Small 10.21979/N9/GXDXOJ This is the peer reviewed version of the following article: Than, A., Duong, P. K., Zan, P., Liu, J., Leow, M. K. & Chen, P. (2020). Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases. Small, 16(31), e2002872-. https://dx.doi.org/10.1002/smll.202002872, which has been published in final form at https://doi.org/10.1002/smll.202002872. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Engineering Transdermal Drug Delivery Controlled Release Than, Aung Duong, Phan Khanh Zan, Ping Liu, Junjie Leow, Melvin Khee-Shing Chen, Peng Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title | Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title_full | Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title_fullStr | Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title_full_unstemmed | Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title_short | Lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| title_sort | lancing drug reservoirs into subcutaneous fat to combat obesity and associated metabolic diseases |
| topic | Engineering Transdermal Drug Delivery Controlled Release |
| url | https://hdl.handle.net/10356/147527 |
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