Antimicrobial microneedle patch for treating deep cutaneous fungal infection
Subcutaneous fungal infection is often difficult to be treated by the conventional topical application or oral intake of antifungal agents because of low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. Here, a new strategy using p...
| Main Authors: | , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/147531 |
| _version_ | 1826121741782482944 |
|---|---|
| author | Zan, Ping Than, Aung Duong, Phan Khanh Song, Juha Xu, Chuanhui Chen, Peng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zan, Ping Than, Aung Duong, Phan Khanh Song, Juha Xu, Chuanhui Chen, Peng |
| author_sort | Zan, Ping |
| collection | NTU |
| description | Subcutaneous fungal infection is often difficult to be treated by the conventional topical application or oral intake of antifungal agents because of low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. Here, a new strategy using polymeric microneedle (MN) patches to overcome the skin barrier is reported. MN is made of a biocompatible and biodegradable chitosan–polyethylenimine copolymer, which possesses antimicrobial property immune to drug resistance and allows sustained drug release. Using a fungal infection mouse model, it is demonstrated that MN patches encapsulated with antifungal agent amphotericin B offer outstanding treatment effectiveness. It is attributable to the high bioavailability of therapeutics and synergistic actions of the antifungal polymer and drug. |
| first_indexed | 2024-10-01T05:37:08Z |
| format | Journal Article |
| id | ntu-10356/147531 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:37:08Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1475312023-12-29T06:49:29Z Antimicrobial microneedle patch for treating deep cutaneous fungal infection Zan, Ping Than, Aung Duong, Phan Khanh Song, Juha Xu, Chuanhui Chen, Peng School of Chemical and Biomedical Engineering Innovative Centre for Flexible Devices Engineering Microneedles Fungal Infection Subcutaneous fungal infection is often difficult to be treated by the conventional topical application or oral intake of antifungal agents because of low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. Here, a new strategy using polymeric microneedle (MN) patches to overcome the skin barrier is reported. MN is made of a biocompatible and biodegradable chitosan–polyethylenimine copolymer, which possesses antimicrobial property immune to drug resistance and allows sustained drug release. Using a fungal infection mouse model, it is demonstrated that MN patches encapsulated with antifungal agent amphotericin B offer outstanding treatment effectiveness. It is attributable to the high bioavailability of therapeutics and synergistic actions of the antifungal polymer and drug. Ministry of Education (MOE) This research was supported by Ministry of Education - Singapore (MOE AcRF Tier 1: RG52/17). 2021-04-06T07:38:23Z 2021-04-06T07:38:23Z 2019 Journal Article Zan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064 2366-3987 https://hdl.handle.net/10356/147531 10.1002/adtp.201900064 10 2 1900064 en Advanced Therapeutics 10.21979/N9/96LHKL This is the peer reviewed version of the following article: Zan, P., Than, A., Duong, P. K., Song, J., Xu, C. & Chen, P. (2019). Antimicrobial microneedle patch for treating deep cutaneous fungal infection. Advanced Therapeutics, 2(10), 1900064-. https://dx.doi.org/10.1002/adtp.201900064, which has been published in final form at https://doi.org/10.1002/adtp.201900064. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Engineering Microneedles Fungal Infection Zan, Ping Than, Aung Duong, Phan Khanh Song, Juha Xu, Chuanhui Chen, Peng Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title | Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title_full | Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title_fullStr | Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title_full_unstemmed | Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title_short | Antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| title_sort | antimicrobial microneedle patch for treating deep cutaneous fungal infection |
| topic | Engineering Microneedles Fungal Infection |
| url | https://hdl.handle.net/10356/147531 |
| work_keys_str_mv | AT zanping antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection AT thanaung antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection AT duongphankhanh antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection AT songjuha antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection AT xuchuanhui antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection AT chenpeng antimicrobialmicroneedlepatchfortreatingdeepcutaneousfungalinfection |