Interferometer-in-spectrometer for high-resolution optical coherence tomography
Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imag...
| Main Authors: | , , , |
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| 其他作者: | |
| 格式: | Journal Article |
| 語言: | English |
| 出版: |
2021
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| 主題: | |
| 在線閱讀: | https://hdl.handle.net/10356/147605 |
| _version_ | 1826129425512529920 |
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| author | Liu, Lishuang Xie, Jun Liu, Linbo Chen, Si |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Liu, Lishuang Xie, Jun Liu, Linbo Chen, Si |
| author_sort | Liu, Lishuang |
| collection | NTU |
| description | Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by spectral shaping without compromising the signal intensity and adding the system cost. The advantage of axial resolution and ranging depth over the standard design is experimentally validated using the standard testing method and fresh swine cornea ex vivo. Moreover, opportunities that opened up by this new scheme for improving the performances of spectral-domain OCT are also discussed. |
| first_indexed | 2024-10-01T07:40:24Z |
| format | Journal Article |
| id | ntu-10356/147605 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:40:24Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1476052021-04-13T08:47:31Z Interferometer-in-spectrometer for high-resolution optical coherence tomography Liu, Lishuang Xie, Jun Liu, Linbo Chen, Si School of Electrical and Electronic Engineering School of Chemical and Biomedical Engineering Engineering::Electrical and electronic engineering Optical Coherence Tomography Spectral Bandwidth Ultrahigh-resolution optical coherence tomography provides an axial resolution of 1-2 μm for resolving cellular structures of biological tissues critical for the diagnosis of diseases. However, it requires a relatively large spectral bandwidth which is not supported by the key components of the imaging system. We propose a novel spectral-domain OCT design, termed interferometer-in-spectrometer, which is able to compensate the bandwidth limitations of the grating and the line scan sensor by spectral shaping without compromising the signal intensity and adding the system cost. The advantage of axial resolution and ranging depth over the standard design is experimentally validated using the standard testing method and fresh swine cornea ex vivo. Moreover, opportunities that opened up by this new scheme for improving the performances of spectral-domain OCT are also discussed. Published version 2021-04-13T08:47:31Z 2021-04-13T08:47:31Z 2020 Journal Article Liu, L., Xie, J., Liu, L. & Chen, S. (2020). Interferometer-in-spectrometer for high-resolution optical coherence tomography. Journal of Sensors, 2020. https://dx.doi.org/10.1155/2020/2530257 1687-725X 0000-0002-7465-0861 0000-0002-4683-9130 https://hdl.handle.net/10356/147605 10.1155/2020/2530257 2-s2.0-85078022595 2020 en Journal of Sensors © 2020 The Author(s). This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. application/pdf |
| spellingShingle | Engineering::Electrical and electronic engineering Optical Coherence Tomography Spectral Bandwidth Liu, Lishuang Xie, Jun Liu, Linbo Chen, Si Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title | Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title_full | Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title_fullStr | Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title_full_unstemmed | Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title_short | Interferometer-in-spectrometer for high-resolution optical coherence tomography |
| title_sort | interferometer in spectrometer for high resolution optical coherence tomography |
| topic | Engineering::Electrical and electronic engineering Optical Coherence Tomography Spectral Bandwidth |
| url | https://hdl.handle.net/10356/147605 |
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