Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization
Ring-opening polymerization of cyclic carbonate monomers is the most common method used to synthesize a range of polycarbonates with unique properties for various applications. This thesis will explore three different areas related to the field of polycarbonates. The first chapter will examine the t...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/147784 |
| _version_ | 1826128503940055040 |
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| author | Tan, Eddy Wei Ping |
| author2 | Xing Bengang |
| author_facet | Xing Bengang Tan, Eddy Wei Ping |
| author_sort | Tan, Eddy Wei Ping |
| collection | NTU |
| description | Ring-opening polymerization of cyclic carbonate monomers is the most common method used to synthesize a range of polycarbonates with unique properties for various applications. This thesis will explore three different areas related to the field of polycarbonates. The first chapter will examine the therapeutic potential of coacervates formed through the complexation of positively charged guanidinium-functionalized antimicrobial polycarbonate with diblock copolymers composed of methoxy poly(ethylene glycol) and negatively charged polycarbonate. The second chapter presents two novel and simple synthetic routes to access cyclic carbonate monomers in bulk while avoiding the use of highly toxic phosgene or chloroformate reagents and tedious protection-deprotection protocols. In the final chapter, the post-polymerization routes for polycarbonate platform were expanded through the development of two new functionalization routes using para-fluoro-thiol SNAr substitution reaction. |
| first_indexed | 2024-10-01T07:26:01Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/147784 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:26:01Z |
| publishDate | 2021 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1477842023-02-28T23:54:08Z Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization Tan, Eddy Wei Ping Xing Bengang School of Physical and Mathematical Sciences A*STAR Institute of Bioengineering and Nanotechnology IBM Research A*STAR Institute of Bioengineering and Nanotechnology Yang Yi Yan Bengang@ntu.edu.sg, yyyang@ibn.a-star.edu.sg Science::Chemistry::Organic chemistry::Polymers Science::Biological sciences::Microbiology::Drug Resistance Ring-opening polymerization of cyclic carbonate monomers is the most common method used to synthesize a range of polycarbonates with unique properties for various applications. This thesis will explore three different areas related to the field of polycarbonates. The first chapter will examine the therapeutic potential of coacervates formed through the complexation of positively charged guanidinium-functionalized antimicrobial polycarbonate with diblock copolymers composed of methoxy poly(ethylene glycol) and negatively charged polycarbonate. The second chapter presents two novel and simple synthetic routes to access cyclic carbonate monomers in bulk while avoiding the use of highly toxic phosgene or chloroformate reagents and tedious protection-deprotection protocols. In the final chapter, the post-polymerization routes for polycarbonate platform were expanded through the development of two new functionalization routes using para-fluoro-thiol SNAr substitution reaction. Doctor of Philosophy 2021-04-19T08:25:32Z 2021-04-19T08:25:32Z 2021 Thesis-Doctor of Philosophy Tan, E. W. P. (2021). Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/147784 https://hdl.handle.net/10356/147784 10.32657/10356/147784 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Science::Chemistry::Organic chemistry::Polymers Science::Biological sciences::Microbiology::Drug Resistance Tan, Eddy Wei Ping Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title | Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title_full | Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title_fullStr | Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title_full_unstemmed | Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title_short | Polycarbonate : antimicrobial polymer delivery, monomer synthesis, rapid polymerization and functionalization |
| title_sort | polycarbonate antimicrobial polymer delivery monomer synthesis rapid polymerization and functionalization |
| topic | Science::Chemistry::Organic chemistry::Polymers Science::Biological sciences::Microbiology::Drug Resistance |
| url | https://hdl.handle.net/10356/147784 |
| work_keys_str_mv | AT taneddyweiping polycarbonateantimicrobialpolymerdeliverymonomersynthesisrapidpolymerizationandfunctionalization |