Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period
The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/147810 |
| _version_ | 1826113233641013248 |
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| author | Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. |
| author_sort | Octavia, Sophie |
| collection | NTU |
| description | The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected. |
| first_indexed | 2024-10-01T03:19:51Z |
| format | Journal Article |
| id | ntu-10356/147810 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:19:51Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1478102023-03-05T16:47:55Z Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Enterobacter Enterobacteriaceae The blaIMI gene is rarely detected outside the Enterobacter genus. Genomic characterization of 87 blaIMI-positive Enterobacter cloacae complex members revealed that the largest phylogenomic clade was made up of E. cloacae subsp. cloacae (71.3%), followed by the newly described species E. bugandensis (13.8%), E. sichuanensis (10.3%), and E. roggenkampii (4.6%). IMI-1 was the predominant carbapenemase variant (86/87, 98.9%). All the blaIMI genes were associated with chromosomally integrated Xer-dependent integrative mobile elements (IMEXs), with two new variants detected. Ministry of Education (MOE) National Medical Research Council (NMRC) Published version Grant support was provided by the NMRC Clinician-Scientist Individual ResearchGrant (NMRC/CIRG/1463/2016), Singapore Ministry of Education Academic ResearchFund Tier 2 grant: New Delhi Metallo-Beta-Lactamase: A global multicenter, whole-genome study (MOE2015-T2-2-096), NMRC Collaborative Grant: Collaborative SolutionsTargeting Antimicrobial Resistance Threats in Health Systems (CoSTAR-HS) (NMRCCGAug16C005), and NMRC Clinician Scientist Award (NMRC/CSA-INV/0002/2016). 2021-04-13T07:23:04Z 2021-04-13T07:23:04Z 2020 Journal Article Octavia, S., Koh, T. H., Ng, O. T., Marimuthu, K., Venkatachalam, I., Lin, R. T. P. & Teo, J. W. P. (2020). Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period. Antimicrobial Agents and Chemotherapy, 64(8). https://dx.doi.org/10.1128/AAC.00510-20 0066-4804 https://hdl.handle.net/10356/147810 10.1128/AAC.00510-20 32482676 2-s2.0-85088610161 8 64 en NMRC/CIRG/1463/2016 MOE2015-T2-2-096 NMRCCGAug16C005 NMRC/CSA-INV/0002/2016 Antimicrobial Agents and Chemotherapy © 2020 American Society for Microbiology. All Rights Reserved. This paper was published in Antimicrobial Agents and Chemotherapy and is made available with permission of American Society for Microbiology. application/pdf |
| spellingShingle | Science::Medicine Enterobacter Enterobacteriaceae Octavia, Sophie Koh, Tse Hsien Ng, Oon Tek Marimuthu, Kalisvar Venkatachalam, Indumathi Lin, Raymond T. P. Teo, Jeanette W. P. Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title_full | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title_fullStr | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title_full_unstemmed | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title_short | Genomic study of blaIMI-positive Enterobacter cloacae complex in Singapore over a five-year study period |
| title_sort | genomic study of blaimi positive enterobacter cloacae complex in singapore over a five year study period |
| topic | Science::Medicine Enterobacter Enterobacteriaceae |
| url | https://hdl.handle.net/10356/147810 |
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