Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering
Polymers are widely used in many applications in the field of biomedical engineering. Among eclectic selections of polymers, those with low melting temperature (Tm < 200 °C), such as poly(methyl methacrylate), poly(lactic-co-glycolic acid), or polyethylene, are often used in bone, dental, maxillo...
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/148723 |
| _version_ | 1826122742930341888 |
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| author | Riau, Andri Kartasasmita Venkatraman, Subbu S. Mehta, Jodhbir Singh |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Riau, Andri Kartasasmita Venkatraman, Subbu S. Mehta, Jodhbir Singh |
| author_sort | Riau, Andri Kartasasmita |
| collection | NTU |
| description | Polymers are widely used in many applications in the field of biomedical engineering. Among eclectic selections of polymers, those with low melting temperature (Tm < 200 °C), such as poly(methyl methacrylate), poly(lactic-co-glycolic acid), or polyethylene, are often used in bone, dental, maxillofacial, and corneal tissue engineering as substrates or scaffolds. These polymers, however, are bioinert, have a lack of reactive surface functional groups, and have poor wettability, affecting their ability to promote cellular functions and biointegration with the surrounding tissue. Improving the biointegration can be achieved by depositing hydroxyapatite (HAp) on the polymeric substrates. Conventional thermal spray and vapor phase coating, including the Food and Drug Administration (FDA)-approved plasma spray technique, is not suitable for application on the low Tm polymers due to the high processing temperature, reaching more than 1000 °C. Two non-thermal HAp coating approaches have been described in the literature, namely, the biomimetic deposition and direct nanoparticle immobilization techniques. In the current review, we elaborate on the unique features of each technique, followed by discussing the advantages and disadvantages of each technique to help readers decide on which method is more suitable for their intended applications. Finally, the future perspectives of the non-thermal HAp coating are given in the conclusion. |
| first_indexed | 2024-10-01T05:53:10Z |
| format | Journal Article |
| id | ntu-10356/148723 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:53:10Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1487232023-07-14T16:02:32Z Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering Riau, Andri Kartasasmita Venkatraman, Subbu S. Mehta, Jodhbir Singh School of Materials Science and Engineering Engineering::Materials Hydroxyapatite Polymer Polymers are widely used in many applications in the field of biomedical engineering. Among eclectic selections of polymers, those with low melting temperature (Tm < 200 °C), such as poly(methyl methacrylate), poly(lactic-co-glycolic acid), or polyethylene, are often used in bone, dental, maxillofacial, and corneal tissue engineering as substrates or scaffolds. These polymers, however, are bioinert, have a lack of reactive surface functional groups, and have poor wettability, affecting their ability to promote cellular functions and biointegration with the surrounding tissue. Improving the biointegration can be achieved by depositing hydroxyapatite (HAp) on the polymeric substrates. Conventional thermal spray and vapor phase coating, including the Food and Drug Administration (FDA)-approved plasma spray technique, is not suitable for application on the low Tm polymers due to the high processing temperature, reaching more than 1000 °C. Two non-thermal HAp coating approaches have been described in the literature, namely, the biomimetic deposition and direct nanoparticle immobilization techniques. In the current review, we elaborate on the unique features of each technique, followed by discussing the advantages and disadvantages of each technique to help readers decide on which method is more suitable for their intended applications. Finally, the future perspectives of the non-thermal HAp coating are given in the conclusion. Published version 2021-05-17T05:07:54Z 2021-05-17T05:07:54Z 2020 Journal Article Riau, A. K., Venkatraman, S. S. & Mehta, J. S. (2020). Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering. Nanomaterials, 10(11). https://dx.doi.org/10.3390/nano10112162 2079-4991 https://hdl.handle.net/10356/148723 10.3390/nano10112162 33138141 2-s2.0-85094583700 11 10 en Nanomaterials © 2020 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Engineering::Materials Hydroxyapatite Polymer Riau, Andri Kartasasmita Venkatraman, Subbu S. Mehta, Jodhbir Singh Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title | Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title_full | Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title_fullStr | Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title_full_unstemmed | Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title_short | Biomimetic vs. direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| title_sort | biomimetic vs direct approach to deposit hydroxyapatite on the surface of low melting point polymers for tissue engineering |
| topic | Engineering::Materials Hydroxyapatite Polymer |
| url | https://hdl.handle.net/10356/148723 |
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