Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study
Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother-child pairs from the Growing Up in Singapore Towards hea...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/148873 |
| _version_ | 1826119231502024704 |
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| author | Lai, Jun S. Veetil, Vaishnavi O. Lanca, Carla Lee, Bee Lan Godfrey, Keith M. Gluckman, Peter D. Shek, Lynette P. Yap, Fabian Tan, Kok Hian Chong, Yap Seng Ong, Choon Nam Ngo, Cheryl S. Saw, Seang-Mei Chong, Mary F. F. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Lai, Jun S. Veetil, Vaishnavi O. Lanca, Carla Lee, Bee Lan Godfrey, Keith M. Gluckman, Peter D. Shek, Lynette P. Yap, Fabian Tan, Kok Hian Chong, Yap Seng Ong, Choon Nam Ngo, Cheryl S. Saw, Seang-Mei Chong, Mary F. F. |
| author_sort | Lai, Jun S. |
| collection | NTU |
| description | Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother-child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions. |
| first_indexed | 2024-10-01T04:56:27Z |
| format | Journal Article |
| id | ntu-10356/148873 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:56:27Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1488732023-03-05T16:44:26Z Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study Lai, Jun S. Veetil, Vaishnavi O. Lanca, Carla Lee, Bee Lan Godfrey, Keith M. Gluckman, Peter D. Shek, Lynette P. Yap, Fabian Tan, Kok Hian Chong, Yap Seng Ong, Choon Nam Ngo, Cheryl S. Saw, Seang-Mei Chong, Mary F. F. Lee Kong Chian School of Medicine (LKCMedicine) Duke-NUS Graduate Medical School Saw Swee Hock School of Public Health Singapore Eye Research Institute Science::Medicine Lutein Zeaxanthin Lutein and zeaxanthin play important roles in visual functions, but their influence on early visual development is unclear. We related maternal lutein and zeaxanthin concentrations during pregnancy to offspring visual acuity (VA) in 471 mother-child pairs from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort. Maternal concentrations of plasma lutein and zeaxanthin were determined at delivery. We measured uncorrected distance of VA in 3-year old children using a LEA Symbols chart; readings were converted to the logarithm of Minimum Angle of Resolution (logMAR), with >0.3 logMAR indicating poor VA. Associations were examined using linear or Poisson regression adjusted for confounders. The median (inter-quartile range) of maternal lutein and zeaxanthin concentrations were 0.13 (0.09, 0.18) and 0.09 (0.07, 0.12) µmol/L, respectively. A total of 126 children had poor VA. The highest tertile of maternal zeaxanthin concentration was associated with 38% lower likelihood of poor VA in children (95% CI: 0.42, 0.93, p-Trends = 0.02). Higher maternal lutein concentrations were associated with a lower likelihood of poor VA in children (RR 0.60 (95% CI: 0.40, 0.88) for middle tertile; RR 0.78 (95% CI: 0.51, 1.19) for highest tertile (p-Quadratic = 0.02)). In conclusion, lutein and zeaxanthin status during pregnancy may influence offspring early visual development; but the results require confirmation with further studies, including more comprehensive measurements of macular functions. Agency for Science, Technology and Research (A*STAR) Ministry of Education (MOE) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version GUSTO was funded by the Singapore National Research Foundation’s Translational and Clinical Research (TCR) Flagship Programme and administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore—NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Singapore Institute for Clinical Sciences, A*STAR, and MOE Academic Research Fund provided additional funding. KMG is supported by the National Institute for Health Research through the NIHR Southampton Biomedical Research Centre and by the European Union’s Seventh Framework Programme (FP7/2007–2013), project Early Nutrition under grant agreement n◦289346. 2021-06-04T05:41:45Z 2021-06-04T05:41:45Z 2020 Journal Article Lai, J. S., Veetil, V. O., Lanca, C., Lee, B. L., Godfrey, K. M., Gluckman, P. D., Shek, L. P., Yap, F., Tan, K. H., Chong, Y. S., Ong, C. N., Ngo, C. S., Saw, S. & Chong, M. F. F. (2020). Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study. Nutrients, 12(2), 274-. https://dx.doi.org/10.3390/nu12020274 2072-6643 https://hdl.handle.net/10356/148873 10.3390/nu12020274 31972973 2-s2.0-85078226272 2 12 274 en NMRC/TCR/004-NUS/2008 NMRC/TCR/012-NUHS/2014 Nutrients © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Lutein Zeaxanthin Lai, Jun S. Veetil, Vaishnavi O. Lanca, Carla Lee, Bee Lan Godfrey, Keith M. Gluckman, Peter D. Shek, Lynette P. Yap, Fabian Tan, Kok Hian Chong, Yap Seng Ong, Choon Nam Ngo, Cheryl S. Saw, Seang-Mei Chong, Mary F. F. Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title | Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title_full | Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title_fullStr | Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title_full_unstemmed | Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title_short | Maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age : the GUSTO study |
| title_sort | maternal lutein and zeaxanthin concentrations in relation to offspring visual acuity at 3 years of age the gusto study |
| topic | Science::Medicine Lutein Zeaxanthin |
| url | https://hdl.handle.net/10356/148873 |
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