RNA interference in glial cells for nerve injury treatment
Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat n...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/148964 |
| _version_ | 1811693232128524288 |
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| author | Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian |
| author_sort | Lin, Junquan |
| collection | NTU |
| description | Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed. |
| first_indexed | 2024-10-01T06:48:24Z |
| format | Journal Article |
| id | ntu-10356/148964 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:48:24Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1489642023-03-05T16:44:24Z RNA interference in glial cells for nerve injury treatment Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) Engineering::Bioengineering RNA Interference Central Nervous System Drivers of RNA interference are potent for manipulating gene and protein levels, which enable the restoration of dysregulated mRNA expression that is commonly associated with injuries and diseases. This review summarizes the potential of targeting neuroglial cells, using RNA interference, to treat nerve injuries sustained in the central nervous system. In addition, the various methods of delivering these RNA interference effectors will be discussed. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) National Research Foundation (NRF) Published version The author(s) disclosed receipt of the following financial support for the research, authorship and/or publication of this article: SY Chew and J Lin would like to acknowledge partial funding support from the Singapore National Research Foundation under its National Medical Research Council Cooperative Basic Research Grant (NMRC-CBRG, NMRC/CBRG/0096/2015) and administered by the Singapore Ministry of Health’s National Medical Research Council; Ministry of Education Tier 1 grant (RG38/19). This research was supported in part by the National Research Foundation (NRF), Republic of Korea (2015K1A1A2032163, 2018K1A4A3A01064257, 2018R1A2B3003446). 2021-06-03T07:53:04Z 2021-06-03T07:53:04Z 2020 Journal Article Lin, J., Jo, S. B., Kim, T., Kim, H. & Chew, S. Y. (2020). RNA interference in glial cells for nerve injury treatment. Journal of Tissue Engineering, 11, 1-17. https://dx.doi.org/10.1177/2041731420939224 2041-7314 0000-0001-6400-6100 0000-0002-6084-5967 https://hdl.handle.net/10356/148964 10.1177/2041731420939224 32670539 2-s2.0-85087475773 11 1 17 en NMRC-CBRG NMRC/CBRG/0096/2015 RG38/19 Journal of Tissue Engineering © 2020 The Author(s). This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). application/pdf |
| spellingShingle | Engineering::Bioengineering RNA Interference Central Nervous System Lin, Junquan Jo, Seung Bin Kim, Tae-Hyun Kim, Hae-Won Chew, Sing Yian RNA interference in glial cells for nerve injury treatment |
| title | RNA interference in glial cells for nerve injury treatment |
| title_full | RNA interference in glial cells for nerve injury treatment |
| title_fullStr | RNA interference in glial cells for nerve injury treatment |
| title_full_unstemmed | RNA interference in glial cells for nerve injury treatment |
| title_short | RNA interference in glial cells for nerve injury treatment |
| title_sort | rna interference in glial cells for nerve injury treatment |
| topic | Engineering::Bioengineering RNA Interference Central Nervous System |
| url | https://hdl.handle.net/10356/148964 |
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