A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection
The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-l...
| Main Authors: | , , , |
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| 其他作者: | |
| 格式: | Journal Article |
| 语言: | English |
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2021
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| 在线阅读: | https://hdl.handle.net/10356/149031 |
| _version_ | 1826113903520645120 |
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| author | Tan, Chew Teng Xu, Xiaoli Qiao, Yuan Wang, Yue |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Tan, Chew Teng Xu, Xiaoli Qiao, Yuan Wang, Yue |
| author_sort | Tan, Chew Teng |
| collection | NTU |
| description | The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of C. albicans. We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive Staphylococcus aureus. Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining C. albicans in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for C. albicans infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence. |
| first_indexed | 2024-10-01T03:30:54Z |
| format | Journal Article |
| id | ntu-10356/149031 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:30:54Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1490312023-02-28T19:26:36Z A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection Tan, Chew Teng Xu, Xiaoli Qiao, Yuan Wang, Yue School of Physical and Mathematical Sciences Science Candida Albicans Microbiota The commensal fungus Candida albicans often causes life-threatening infections in patients who are immunocompromised with high mortality. A prominent but poorly understood risk factor for the C. albicans commensal‒pathogen transition is the use of broad-spectrum antibiotics. Here, we report that β-lactam antibiotics cause bacteria to release significant quantities of peptidoglycan fragments that potently induce the invasive hyphal growth of C. albicans. We identify several active peptidoglycan subunits, including tracheal cytotoxin, a molecule produced by many Gram-negative bacteria, and fragments purified from the cell wall of Gram-positive Staphylococcus aureus. Feeding mice with β-lactam antibiotics causes a peptidoglycan storm that transforms the gut from a niche usually restraining C. albicans in the commensal state to promoting invasive growth, leading to systemic dissemination. Our findings reveal a mechanism underlying a significant risk factor for C. albicans infection, which could inform clinicians regarding future antibiotic selection to minimize this deadly disease incidence. National Medical Research Council (NMRC) Published version 2021-05-21T01:30:00Z 2021-05-21T01:30:00Z 2021 Journal Article Tan, C. T., Xu, X., Qiao, Y. & Wang, Y. (2021). A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection. Nature Communications, 12(1), 2560-. https://dx.doi.org/10.1038/s41467-021-22845-2 2041-1723 https://hdl.handle.net/10356/149031 10.1038/s41467-021-22845-2 33963193 1 12 2560 en Nature Communications © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. application/pdf |
| spellingShingle | Science Candida Albicans Microbiota Tan, Chew Teng Xu, Xiaoli Qiao, Yuan Wang, Yue A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title | A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title_full | A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title_fullStr | A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title_full_unstemmed | A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title_short | A peptidoglycan storm caused by β-lactam antibiotic's action on host microbiota drives Candida albicans infection |
| title_sort | peptidoglycan storm caused by β lactam antibiotic s action on host microbiota drives candida albicans infection |
| topic | Science Candida Albicans Microbiota |
| url | https://hdl.handle.net/10356/149031 |
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