Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014
Background: Few studies have evaluated the relative cross-protection conferred by infection with different groups of viruses through studies of sequential infections in humans. We investigated the presence of short-lived relative cross-protection conferred by specific prior viral infections against...
| Main Authors: | , , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/149046 |
| _version_ | 1811697676640583680 |
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| author | Chen, Mark I-Cheng Loh, Jin Phang Chuah, Cheryl X. P. Gao, Christine Qiu Han Sun, Yinxiaohe Ng, Sock Hoon Koh, Victor Wee-Hong Goh, Ee Hui Zhao, Xiahong Tambyah, Paul Anantharajah Cook, Alex R. Chng, Jeremiah Pang, Junxiong Tan, Boon Huan Lee, Vernon J. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chen, Mark I-Cheng Loh, Jin Phang Chuah, Cheryl X. P. Gao, Christine Qiu Han Sun, Yinxiaohe Ng, Sock Hoon Koh, Victor Wee-Hong Goh, Ee Hui Zhao, Xiahong Tambyah, Paul Anantharajah Cook, Alex R. Chng, Jeremiah Pang, Junxiong Tan, Boon Huan Lee, Vernon J. |
| author_sort | Chen, Mark I-Cheng |
| collection | NTU |
| description | Background:
Few studies have evaluated the relative cross-protection conferred by infection with different groups of viruses through studies of sequential infections in humans. We investigated the presence of short-lived relative cross-protection conferred by specific prior viral infections against subsequent febrile respiratory illness (FRI).
Methods:
Men enlisted in basic military training between December 2009 and December 2014 were recruited, with the first FRI as the study entry point. ResPlex II assays and real-time polymerase chain reaction assays were used to detect viral pathogens in nasal wash samples, and survival analyses were performed to determine whether infection with particular viruses conferred short-lived relative cross-protection against FRI.
Results:
Prior infection with adenovirus (hazard ratio [HR], 0.24; 95% confidence interval [CI], .14–.44) or influenza virus (HR, 0.52; 95% CI, .38–.73) conferred relative protection against subsequent FRI episode. Results were statistically significant even after adjustment for the interval between enlistment and FRI (P < .001). Adenovirus-positive participants with FRI episodes tended to be protected against subsequent infection with adenovirus, coronavirus, enterovirus/rhinovirus, and influenza virus (P = .062–.093), while men with influenza virus–positive FRI episodes tended be protected against subsequent infection with adenovirus (P = .044) and influenza virus (P = .081).
Conclusion:
Prior adenovirus or influenza virus infection conferred cross-protection against subsequent FRI episodes relative to prior infection due to other circulating viruses. |
| first_indexed | 2024-10-01T07:59:03Z |
| format | Journal Article |
| id | ntu-10356/149046 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:59:03Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1490462023-03-05T16:45:04Z Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 Chen, Mark I-Cheng Loh, Jin Phang Chuah, Cheryl X. P. Gao, Christine Qiu Han Sun, Yinxiaohe Ng, Sock Hoon Koh, Victor Wee-Hong Goh, Ee Hui Zhao, Xiahong Tambyah, Paul Anantharajah Cook, Alex R. Chng, Jeremiah Pang, Junxiong Tan, Boon Huan Lee, Vernon J. Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Antibodies Cell-mediated Immunity Background: Few studies have evaluated the relative cross-protection conferred by infection with different groups of viruses through studies of sequential infections in humans. We investigated the presence of short-lived relative cross-protection conferred by specific prior viral infections against subsequent febrile respiratory illness (FRI). Methods: Men enlisted in basic military training between December 2009 and December 2014 were recruited, with the first FRI as the study entry point. ResPlex II assays and real-time polymerase chain reaction assays were used to detect viral pathogens in nasal wash samples, and survival analyses were performed to determine whether infection with particular viruses conferred short-lived relative cross-protection against FRI. Results: Prior infection with adenovirus (hazard ratio [HR], 0.24; 95% confidence interval [CI], .14–.44) or influenza virus (HR, 0.52; 95% CI, .38–.73) conferred relative protection against subsequent FRI episode. Results were statistically significant even after adjustment for the interval between enlistment and FRI (P < .001). Adenovirus-positive participants with FRI episodes tended to be protected against subsequent infection with adenovirus, coronavirus, enterovirus/rhinovirus, and influenza virus (P = .062–.093), while men with influenza virus–positive FRI episodes tended be protected against subsequent infection with adenovirus (P = .044) and influenza virus (P = .081). Conclusion: Prior adenovirus or influenza virus infection conferred cross-protection against subsequent FRI episodes relative to prior infection due to other circulating viruses. Ministry of Defence (MINDEF) Ministry of Education (MOE) Published version This work was supported by the Ministry of Education (tier 1 grant R-608-000-132-112 to C. X. P. C.) and by the Centre for Infectious Disease Epidemiology and Research, Saw Swee Hock School of Public Health (funded by the Singapore Ministry of Defence). 2021-05-11T06:00:27Z 2021-05-11T06:00:27Z 2019 Journal Article Chen, M. I., Loh, J. P., Chuah, C. X. P., Gao, C. Q. H., Sun, Y., Ng, S. H., Koh, V. W., Goh, E. H., Zhao, X., Tambyah, P. A., Cook, A. R., Chng, J., Pang, J., Tan, B. H. & Lee, V. J. (2019). Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014. Journal of Infectious Diseases, 219(12), 1913-1923. https://dx.doi.org/10.1093/infdis/jiz046 0022-1899 https://hdl.handle.net/10356/149046 10.1093/infdis/jiz046 30722024 2-s2.0-85066944628 12 219 1913 1923 en R-608-000-132-112 Journal of Infectious Diseases © 2019 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com DOI: 10.1093/infdis/jiz046 application/pdf |
| spellingShingle | Science::Medicine Antibodies Cell-mediated Immunity Chen, Mark I-Cheng Loh, Jin Phang Chuah, Cheryl X. P. Gao, Christine Qiu Han Sun, Yinxiaohe Ng, Sock Hoon Koh, Victor Wee-Hong Goh, Ee Hui Zhao, Xiahong Tambyah, Paul Anantharajah Cook, Alex R. Chng, Jeremiah Pang, Junxiong Tan, Boon Huan Lee, Vernon J. Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title | Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title_full | Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title_fullStr | Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title_full_unstemmed | Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title_short | Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 |
| title_sort | evidence for cross protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among singapore military recruits 2009 2014 |
| topic | Science::Medicine Antibodies Cell-mediated Immunity |
| url | https://hdl.handle.net/10356/149046 |
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