Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells
The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as w...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/149237 |
| _version_ | 1826118562955132928 |
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| author | Kwek, Zheng Hua Ganguly, Rakesh Afreen, A. Mohamed Koh, Wei Xiang Leong, Weng Kee Tan, Kelvin Yong Leng |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Kwek, Zheng Hua Ganguly, Rakesh Afreen, A. Mohamed Koh, Wei Xiang Leong, Weng Kee Tan, Kelvin Yong Leng |
| author_sort | Kwek, Zheng Hua |
| collection | NTU |
| description | The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated. |
| first_indexed | 2024-10-01T04:45:30Z |
| format | Journal Article |
| id | ntu-10356/149237 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:45:30Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1492372023-02-28T19:38:02Z Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells Kwek, Zheng Hua Ganguly, Rakesh Afreen, A. Mohamed Koh, Wei Xiang Leong, Weng Kee Tan, Kelvin Yong Leng School of Physical and Mathematical Sciences Science::Chemistry Science::Chemistry::Inorganic chemistry Benzaldehyde Carboxylato The activated cluster Os3(CO)10(CH3CN)2 (1) reacts readily with a number of carboxylated chalcones and benzaldehydes (2a−j) to afford products with the general formula Os3(CO)10(µ-H)(µ-O2CR) (3a–j). The structures of all the novel clusters have been characterized by IR and 1H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated. Ministry of Education (MOE) Accepted version M4011793 2021-05-24T01:10:01Z 2021-05-24T01:10:01Z 2020 Journal Article Kwek, Z. H., Ganguly, R., Afreen, A. M., Koh, W. X., Leong, W. K. & Tan, K. Y. L. (2020). Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells. Journal of Cluster Science, 31(4), 759-767. https://dx.doi.org/10.1007/s10876-019-01684-8 1040-7278 https://hdl.handle.net/10356/149237 10.1007/s10876-019-01684-8 2-s2.0-85074046452 4 31 759 767 en Journal of Cluster Science © 2019 Springer Science+Business Media. This is a post-peer-review, pre-copyedit version of an article published in Journal of Cluster Science. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10876-019-01684-8 application/pdf |
| spellingShingle | Science::Chemistry Science::Chemistry::Inorganic chemistry Benzaldehyde Carboxylato Kwek, Zheng Hua Ganguly, Rakesh Afreen, A. Mohamed Koh, Wei Xiang Leong, Weng Kee Tan, Kelvin Yong Leng Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title | Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title_full | Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title_fullStr | Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title_full_unstemmed | Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title_short | Carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters : synthesis, characterization and biological activity towards MCF-7 cells |
| title_sort | carboxylated chalcone and benzaldehyde derivatives of triosmium carbonyl clusters synthesis characterization and biological activity towards mcf 7 cells |
| topic | Science::Chemistry Science::Chemistry::Inorganic chemistry Benzaldehyde Carboxylato |
| url | https://hdl.handle.net/10356/149237 |
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