Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial
Background: Sepsis in patients with cancer is increasingly common and associated with high mortality. To date, no studies have examined the effectiveness of prehospital antibiotics in septic patients with cancer. This study aimed to compare survival of septic patients with cancer to those without an...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | http://www.njmonline.nl/article_ft.php?a=2179&d=1438&i=232 https://hdl.handle.net/10356/149239 |
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| author | Panday, Rishi Nannan Wang, S. Schermer, E. H. Cooksley, T. Alam, N. Nanayakkara, P. W. B. |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Panday, Rishi Nannan Wang, S. Schermer, E. H. Cooksley, T. Alam, N. Nanayakkara, P. W. B. |
| author_sort | Panday, Rishi Nannan |
| collection | NTU |
| description | Background: Sepsis in patients with cancer is increasingly common and associated with high mortality. To date, no studies have examined the effectiveness of prehospital antibiotics in septic patients with cancer. This study aimed to compare survival of septic patients with cancer to those without and to evaluate the effect of prehospital antibiotics in septic patients with cancer. Methods: We conducted a post-hoc sub-analysis of the PHANTASi (PreHospital ANTibioitcs Against Sepsis) trial database: a randomised controlled trial which enrolled patients with suspected sepsis who were transported to the emergency department by ambulance. Patients in the intervention group were administered prehospital intravenous antibiotics while those in the control group received usual care. We compared patients who had cancer to those who did not. Primary outcome was 28-day mortality; among the secondary outcomes, we included in-hospital mortality and 90-day mortality. Results: 357(13.4%) of the 2658 included patients had cancer in the past five years, of which, 209 (58.5%) were included in the intervention and 148 (41.5%) usual care groups; 28-day mortality was significantly higher in patients who were diagnosed with cancer in the past five years than those without cancer in the past five years: 15.2% vs. 7.1%, respectively (p < 0.001). Prehospital antibiotics in the group of patients with cancer in the last five years yielded no significant effect on survival. There were however, significantly fewer 30-day readmissions (p = 0.031) in the intervention group of cancer patients (12.2% vs 5.7%). Conclusion: Prehospital antibiotics did not improve overall survival. However, there was a significant reduction in 30-day readmissions. |
| first_indexed | 2025-02-19T03:37:39Z |
| format | Journal Article |
| id | ntu-10356/149239 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:37:39Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1492392023-03-05T16:49:35Z Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial Panday, Rishi Nannan Wang, S. Schermer, E. H. Cooksley, T. Alam, N. Nanayakkara, P. W. B. Lee Kong Chian School of Medicine (LKCMedicine) Centre for Population Health Sciences Science::Medicine Cancer Mortality Background: Sepsis in patients with cancer is increasingly common and associated with high mortality. To date, no studies have examined the effectiveness of prehospital antibiotics in septic patients with cancer. This study aimed to compare survival of septic patients with cancer to those without and to evaluate the effect of prehospital antibiotics in septic patients with cancer. Methods: We conducted a post-hoc sub-analysis of the PHANTASi (PreHospital ANTibioitcs Against Sepsis) trial database: a randomised controlled trial which enrolled patients with suspected sepsis who were transported to the emergency department by ambulance. Patients in the intervention group were administered prehospital intravenous antibiotics while those in the control group received usual care. We compared patients who had cancer to those who did not. Primary outcome was 28-day mortality; among the secondary outcomes, we included in-hospital mortality and 90-day mortality. Results: 357(13.4%) of the 2658 included patients had cancer in the past five years, of which, 209 (58.5%) were included in the intervention and 148 (41.5%) usual care groups; 28-day mortality was significantly higher in patients who were diagnosed with cancer in the past five years than those without cancer in the past five years: 15.2% vs. 7.1%, respectively (p < 0.001). Prehospital antibiotics in the group of patients with cancer in the last five years yielded no significant effect on survival. There were however, significantly fewer 30-day readmissions (p = 0.031) in the intervention group of cancer patients (12.2% vs 5.7%). Conclusion: Prehospital antibiotics did not improve overall survival. However, there was a significant reduction in 30-day readmissions. Published version 2021-05-29T05:50:53Z 2021-05-29T05:50:53Z 2020 Journal Article Panday, R. N., Wang, S., Schermer, E. H., Cooksley, T., Alam, N. & Nanayakkara, P. W. B. (2020). Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial. The Netherlands Journal of Medicine, 78(1), 3-9. 0300-2977 http://www.njmonline.nl/article_ft.php?a=2179&d=1438&i=232 https://hdl.handle.net/10356/149239 1 78 3 9 en The Netherlands Journal of Medicine © 2020 MacChain. All rights reserved. This paper was published in The Netherlands Journal of Medicine and is made available with permission of MacChain. application/pdf |
| spellingShingle | Science::Medicine Cancer Mortality Panday, Rishi Nannan Wang, S. Schermer, E. H. Cooksley, T. Alam, N. Nanayakkara, P. W. B. Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title | Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title_full | Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title_fullStr | Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title_full_unstemmed | Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title_short | Septic patients with cancer : do prehospital antibiotics improve survival? A sub-analysis of the PHANTASi trial |
| title_sort | septic patients with cancer do prehospital antibiotics improve survival a sub analysis of the phantasi trial |
| topic | Science::Medicine Cancer Mortality |
| url | http://www.njmonline.nl/article_ft.php?a=2179&d=1438&i=232 https://hdl.handle.net/10356/149239 |
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