Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort
Background and purpose: Cognitive impairment, slow walking speed and motoric cognitive risk syndrome (MCR) have separately been associated with an increased risk for mortality in the short term. The aim of the study was to examine the association of MCR and its components [i.e. subjective cognitive...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/150231 |
| _version_ | 1811687707817017344 |
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| author | Beauchet, Olivier Sekhon, Harmehr Launay, Cyrille Patrice Chabot, Julia Rolland, Yves M. Schott, Anne-Marie Allali, Gilles |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Beauchet, Olivier Sekhon, Harmehr Launay, Cyrille Patrice Chabot, Julia Rolland, Yves M. Schott, Anne-Marie Allali, Gilles |
| author_sort | Beauchet, Olivier |
| collection | NTU |
| description | Background and purpose: Cognitive impairment, slow walking speed and motoric cognitive risk syndrome (MCR) have separately been associated with an increased risk for mortality in the short term. The aim of the study was to examine the association of MCR and its components [i.e. subjective cognitive complaint (SCC) and slow walking speed] with short-, medium- and long-term mortality in older community-dwellers. Methods: In all, 3778 participants from the Epidémiologie de l'Ostéoporose (EPIDOS) study were selected. MCR was defined as the combination of slow walking speed and SCC in participants without major neurocognitive disorders. Deaths were prospectively recorded using mail, phone calls, questionnaires and/or the French national death registry at 5, 10, 15 and 19 (end of follow‐up period) years. Results: Over the follow‐up of 19 years, 80.5% (n = 3043) participants died. Slow walking speed and MCR were associated with mortality [hazard ratio (HR) 1.20 with P = 0.004 for slow walking speed and HR = 1.26 with P = 0.002 for MCR at 10 years; HR = 1.27 with P ≤ 0.001 for slow walking speed and HR = 1.22 with P = 0.001 for MCR at 15 years; HR = 1.41 with P ≤ 0.001 at 19 years for slow walking speed and MCR]. There was no association between SCC and mortality. Kaplan–Meier distributions of mortality showed that participants with MCR and slow walking speed died earlier compared to healthy participants and those with SCC (P < 0.001). Conclusions: Slow walking speed and MCR were associated with an increased risk for mortality at the medium and long term, whereas no association was found with SCC. |
| first_indexed | 2024-10-01T05:20:36Z |
| format | Journal Article |
| id | ntu-10356/150231 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:20:36Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1502312021-06-08T08:28:17Z Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort Beauchet, Olivier Sekhon, Harmehr Launay, Cyrille Patrice Chabot, Julia Rolland, Yves M. Schott, Anne-Marie Allali, Gilles Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Cognition Cohort Study Background and purpose: Cognitive impairment, slow walking speed and motoric cognitive risk syndrome (MCR) have separately been associated with an increased risk for mortality in the short term. The aim of the study was to examine the association of MCR and its components [i.e. subjective cognitive complaint (SCC) and slow walking speed] with short-, medium- and long-term mortality in older community-dwellers. Methods: In all, 3778 participants from the Epidémiologie de l'Ostéoporose (EPIDOS) study were selected. MCR was defined as the combination of slow walking speed and SCC in participants without major neurocognitive disorders. Deaths were prospectively recorded using mail, phone calls, questionnaires and/or the French national death registry at 5, 10, 15 and 19 (end of follow‐up period) years. Results: Over the follow‐up of 19 years, 80.5% (n = 3043) participants died. Slow walking speed and MCR were associated with mortality [hazard ratio (HR) 1.20 with P = 0.004 for slow walking speed and HR = 1.26 with P = 0.002 for MCR at 10 years; HR = 1.27 with P ≤ 0.001 for slow walking speed and HR = 1.22 with P = 0.001 for MCR at 15 years; HR = 1.41 with P ≤ 0.001 at 19 years for slow walking speed and MCR]. There was no association between SCC and mortality. Kaplan–Meier distributions of mortality showed that participants with MCR and slow walking speed died earlier compared to healthy participants and those with SCC (P < 0.001). Conclusions: Slow walking speed and MCR were associated with an increased risk for mortality at the medium and long term, whereas no association was found with SCC. 2021-06-08T08:28:17Z 2021-06-08T08:28:17Z 2019 Journal Article Beauchet, O., Sekhon, H., Launay, C. P., Chabot, J., Rolland, Y. M., Schott, A. & Allali, G. (2019). Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort. European Journal of Neurology, 26(5), 794-e56. https://dx.doi.org/10.1111/ene.13891 1351-5101 0000-0003-1921-9443 0000-0002-4455-6719 https://hdl.handle.net/10356/150231 10.1111/ene.13891 30589153 2-s2.0-85060969000 5 26 794 e56 en European Journal of Neurology © 2018 EAN. All rights reserved. |
| spellingShingle | Science::Medicine Cognition Cohort Study Beauchet, Olivier Sekhon, Harmehr Launay, Cyrille Patrice Chabot, Julia Rolland, Yves M. Schott, Anne-Marie Allali, Gilles Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title | Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title_full | Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title_fullStr | Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title_full_unstemmed | Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title_short | Motoric cognitive risk syndrome and mortality : results from the EPIDOS cohort |
| title_sort | motoric cognitive risk syndrome and mortality results from the epidos cohort |
| topic | Science::Medicine Cognition Cohort Study |
| url | https://hdl.handle.net/10356/150231 |
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