A longitudinal study of choroidal changes following cataract surgery in patients with diabetes
Objective: To study the structural changes in the choroid of diabetic patients following cataract surgery, using choroidal vascularity index and choroidal thickness. Methods: A prospective case–control study was conducted in 18 diabetic and 18 non-diabetic patients undergoing cataract surgery (phaco...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/150727 |
| _version_ | 1826124488104738816 |
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| author | Yip, Vivien Cherng-Hui Laude, Augustinus Tan, Kara Anne Ding, Jianbin Wong, Elizabeth Agrawal, Rupesh |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Yip, Vivien Cherng-Hui Laude, Augustinus Tan, Kara Anne Ding, Jianbin Wong, Elizabeth Agrawal, Rupesh |
| author_sort | Yip, Vivien Cherng-Hui |
| collection | NTU |
| description | Objective: To study the structural changes in the choroid of diabetic patients following cataract surgery, using choroidal vascularity index and choroidal thickness. Methods: A prospective case–control study was conducted in 18 diabetic and 18 non-diabetic patients undergoing cataract surgery (phacoemulsification) in one eye. Enhanced depth imaging optical coherence tomography images were obtained before and after surgery. Niblack’s image binarization of images was performed to derive the choroidal vascularity index. Independent sample T-test compared the differences of choroidal vascularity index and choroidal thickness between diabetic and non-diabetic patients. Results: The baseline choroidal vascularity index was significantly lower in diabetic patients for both operated (mean difference vs non-diabetic: 0.0184, 95% CI: 0.004–0.0324, p=0.012) and non-operated (mean difference vs non-diabetic: 0.0145, 95% CI: 0.003–0.0256, p=0.012) eyes. Choroidal thickness increased following cataract surgery (diabetes: mean difference=12.4, 95% CI: 0.70–24.0, adjusted p=0.036; non-diabetic: mean difference=21.0, 95% CI: 4.39–37.6, adjusted p=0.011). Conclusion: Diabetic patients have reduced choroidal vascularity index than non-diabetic patients, suggestive of possible reduction in choroidal vascularity in diabetes. Choroidal thickness increased following cataract surgery in both diabetic and non-diabetic patients. |
| first_indexed | 2024-10-01T06:21:26Z |
| format | Journal Article |
| id | ntu-10356/150727 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:21:26Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1507272021-06-14T05:48:53Z A longitudinal study of choroidal changes following cataract surgery in patients with diabetes Yip, Vivien Cherng-Hui Laude, Augustinus Tan, Kara Anne Ding, Jianbin Wong, Elizabeth Agrawal, Rupesh Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Diabetic Retinopathy Diabetes Objective: To study the structural changes in the choroid of diabetic patients following cataract surgery, using choroidal vascularity index and choroidal thickness. Methods: A prospective case–control study was conducted in 18 diabetic and 18 non-diabetic patients undergoing cataract surgery (phacoemulsification) in one eye. Enhanced depth imaging optical coherence tomography images were obtained before and after surgery. Niblack’s image binarization of images was performed to derive the choroidal vascularity index. Independent sample T-test compared the differences of choroidal vascularity index and choroidal thickness between diabetic and non-diabetic patients. Results: The baseline choroidal vascularity index was significantly lower in diabetic patients for both operated (mean difference vs non-diabetic: 0.0184, 95% CI: 0.004–0.0324, p=0.012) and non-operated (mean difference vs non-diabetic: 0.0145, 95% CI: 0.003–0.0256, p=0.012) eyes. Choroidal thickness increased following cataract surgery (diabetes: mean difference=12.4, 95% CI: 0.70–24.0, adjusted p=0.036; non-diabetic: mean difference=21.0, 95% CI: 4.39–37.6, adjusted p=0.011). Conclusion: Diabetic patients have reduced choroidal vascularity index than non-diabetic patients, suggestive of possible reduction in choroidal vascularity in diabetes. Choroidal thickness increased following cataract surgery in both diabetic and non-diabetic patients. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by Pitch-For-Fund grant administered by Tan Tock Seng Hospital in 2012. 2021-06-14T05:47:40Z 2021-06-14T05:47:40Z 2019 Journal Article Yip, V. C., Laude, A., Tan, K. A., Ding, J., Wong, E. & Agrawal, R. (2019). A longitudinal study of choroidal changes following cataract surgery in patients with diabetes. Diabetes & Vascular Disease Research, 16(4), 369-377. https://dx.doi.org/10.1177/1479164119841536 1479-1641 0000-0002-6662-5850 https://hdl.handle.net/10356/150727 10.1177/1479164119841536 31007056 2-s2.0-85064849065 4 16 369 377 en Diabetes & Vascular Disease Research © 2019 The Author(s). All rights reserved. |
| spellingShingle | Science::Medicine Diabetic Retinopathy Diabetes Yip, Vivien Cherng-Hui Laude, Augustinus Tan, Kara Anne Ding, Jianbin Wong, Elizabeth Agrawal, Rupesh A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title | A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title_full | A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title_fullStr | A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title_full_unstemmed | A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title_short | A longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| title_sort | longitudinal study of choroidal changes following cataract surgery in patients with diabetes |
| topic | Science::Medicine Diabetic Retinopathy Diabetes |
| url | https://hdl.handle.net/10356/150727 |
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