Generation of a heteropolycyclic and sp3-rich scaffold for library synthesis from a highly diastereoselective Petasis/Diels–Alder and ROM–RCM reaction sequence

Generation of a heteropolycyclic and sp3-rich scaffold for library synthesis from a highly diastereoselective Petasis/Diels–Alder and ROM–RCM reaction sequence

Efficient access to diverse screening compounds with desirable, lead-like properties can be a bottleneck in early drug discovery and chemical biology. Herein we present an efficient, rapid route to three structurally distinct classes of compounds (A–C) from a single precursor, which in turn is avail...

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Bibliographic Details
Main Authors: Flagstad, Thomas, Azevedo, Carlos M. G., Troelsen, Nikolaj S., Min, Geanna K., Macé, Yohan, Willaume, Anthony, Guilleux, Rachel, Velay, Mélanie, Bonnet, Karine, Morgentin, Remy, Nielsen, Thomas E., Clausen, Mads H.
Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
Format: Journal Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Drug Discovery
Heterocycles
Online Access:https://hdl.handle.net/10356/150792

Internet

https://hdl.handle.net/10356/150792

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