Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly successful intracellular pathogen with the ability to withstand harsh conditions and reside long-term within its host. In the dormant and persistent states, the bacterium tunes its metabolism and is able to resis...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/151058 |
| _version_ | 1826117030993985536 |
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| author | Chang, Dorothy Pei Shan Guan, Xue Li |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chang, Dorothy Pei Shan Guan, Xue Li |
| author_sort | Chang, Dorothy Pei Shan |
| collection | NTU |
| description | Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly successful intracellular pathogen with the ability to withstand harsh conditions and reside long-term within its host. In the dormant and persistent states, the bacterium tunes its metabolism and is able to resist the actions of antibiotics. One of the main strategies Mtb adopts is through its metabolic versatility—it is able to cometabolize a variety of essential nutrients and direct these nutrients simultaneously to multiple metabolic pathways to facilitate the infection of the host. Mtb further undergo extensive remodeling of its metabolic pathways in response to stress and dormancy. In recent years, advancement in systems biology and its applications have contributed substantially to a more coherent view on the intricate metabolic networks of Mtb. With a more refined appreciation of the roles of metabolism in mycobacterial infection and drug resistance, and the success of drugs targeting metabolism, there is growing interest in further development of anti-TB therapies that target metabolism, including lipid metabolism and oxidative phosphorylation. Here, we will review current knowledge revolving around the versatility of Mtb in remodeling its metabolism during infection and dormancy, with a focus on central carbon metabolism and lipid metabolism. |
| first_indexed | 2024-10-01T04:21:07Z |
| format | Journal Article |
| id | ntu-10356/151058 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:21:07Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1510582023-03-05T16:50:44Z Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy Chang, Dorothy Pei Shan Guan, Xue Li Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Metabolism Mycobacterium Tuberculosis Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly successful intracellular pathogen with the ability to withstand harsh conditions and reside long-term within its host. In the dormant and persistent states, the bacterium tunes its metabolism and is able to resist the actions of antibiotics. One of the main strategies Mtb adopts is through its metabolic versatility—it is able to cometabolize a variety of essential nutrients and direct these nutrients simultaneously to multiple metabolic pathways to facilitate the infection of the host. Mtb further undergo extensive remodeling of its metabolic pathways in response to stress and dormancy. In recent years, advancement in systems biology and its applications have contributed substantially to a more coherent view on the intricate metabolic networks of Mtb. With a more refined appreciation of the roles of metabolism in mycobacterial infection and drug resistance, and the success of drugs targeting metabolism, there is growing interest in further development of anti-TB therapies that target metabolism, including lipid metabolism and oxidative phosphorylation. Here, we will review current knowledge revolving around the versatility of Mtb in remodeling its metabolism during infection and dormancy, with a focus on central carbon metabolism and lipid metabolism. Ministry of Education (MOE) Nanyang Technological University Published version Work in the laboratory of X.L.G. is supported by the Nanyang Assistant Professorship Start-up Grant from Lee Kong Chian School of Medicine, Nanyang Technological University Singapore; and the Ministry of Education (MOE) Tier 2 grant (MOE2017-T2-1-042). D.P.S.C. is supported by a Nanyang Technological University Graduate Research Scholarship. 2021-06-25T08:35:06Z 2021-06-25T08:35:06Z 2021 Journal Article Chang, D. P. S. & Guan, X. L. (2021). Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy. Metabolites, 11(2), 88-. https://dx.doi.org/10.3390/metabo11020088 2218-1989 0000-0001-7051-7935 https://hdl.handle.net/10356/151058 10.3390/metabo11020088 33540752 2-s2.0-85100757018 2 11 88 en MOE2017-T2-1-042 Metabolites © 2021 The Authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). application/pdf |
| spellingShingle | Science::Medicine Metabolism Mycobacterium Tuberculosis Chang, Dorothy Pei Shan Guan, Xue Li Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title | Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title_full | Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title_fullStr | Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title_full_unstemmed | Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title_short | Metabolic versatility of Mycobacterium tuberculosis during infection and dormancy |
| title_sort | metabolic versatility of mycobacterium tuberculosis during infection and dormancy |
| topic | Science::Medicine Metabolism Mycobacterium Tuberculosis |
| url | https://hdl.handle.net/10356/151058 |
| work_keys_str_mv | AT changdorothypeishan metabolicversatilityofmycobacteriumtuberculosisduringinfectionanddormancy AT guanxueli metabolicversatilityofmycobacteriumtuberculosisduringinfectionanddormancy |