Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells
We report multiscale structured fibers and patterned films based on a semiconducting polymer, poly(3-hexylthiophene) (P3HT), as photoconductive biointerfaces to promote neuronal stimulation upon light irradiation. The micro/nanoscale structures of P3HT used for neuronal interfacing and stimulation i...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/151247 |
| _version_ | 1811692269761200128 |
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| author | Wu, Yingjie Peng, Yanfen Bohra, Hassan Zou, Jianping Ranjan, Vivek Damodar Zhang, Yilei Zhang, Qing Wang, Mingfeng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wu, Yingjie Peng, Yanfen Bohra, Hassan Zou, Jianping Ranjan, Vivek Damodar Zhang, Yilei Zhang, Qing Wang, Mingfeng |
| author_sort | Wu, Yingjie |
| collection | NTU |
| description | We report multiscale structured fibers and patterned films based on a semiconducting polymer, poly(3-hexylthiophene) (P3HT), as photoconductive biointerfaces to promote neuronal stimulation upon light irradiation. The micro/nanoscale structures of P3HT used for neuronal interfacing and stimulation include nanofibers with an average diameter of 100 nm, microfibers with an average diameter of about 1 μm, and lithographically patterned stripes with width of 3, 25, and 50 μm, respectively. The photoconductive effect of P3HT upon light irradiation provides electrical stimulation for neuronal differentiation and directed growth. Our results demonstrate that neurons on P3HT nanofibers showed a significantly higher total number of branches, while neurons grown on P3HT microfibers had longer and thinner neurites. Such a combination strategy of topographical and photoconductive stimulation can be applied to further enhance neuronal differentiation and directed growth. These photoconductive polymeric micro/nanostructures demonstrated their great potential for neural engineering and development of novel neural regenerative devices. |
| first_indexed | 2024-10-01T06:33:06Z |
| format | Journal Article |
| id | ntu-10356/151247 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:33:06Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1512472021-07-23T10:31:55Z Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells Wu, Yingjie Peng, Yanfen Bohra, Hassan Zou, Jianping Ranjan, Vivek Damodar Zhang, Yilei Zhang, Qing Wang, Mingfeng School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering School of Mechanical and Aerospace Engineering Engineering::Chemical engineering Polymers Semiconductors We report multiscale structured fibers and patterned films based on a semiconducting polymer, poly(3-hexylthiophene) (P3HT), as photoconductive biointerfaces to promote neuronal stimulation upon light irradiation. The micro/nanoscale structures of P3HT used for neuronal interfacing and stimulation include nanofibers with an average diameter of 100 nm, microfibers with an average diameter of about 1 μm, and lithographically patterned stripes with width of 3, 25, and 50 μm, respectively. The photoconductive effect of P3HT upon light irradiation provides electrical stimulation for neuronal differentiation and directed growth. Our results demonstrate that neurons on P3HT nanofibers showed a significantly higher total number of branches, while neurons grown on P3HT microfibers had longer and thinner neurites. Such a combination strategy of topographical and photoconductive stimulation can be applied to further enhance neuronal differentiation and directed growth. These photoconductive polymeric micro/nanostructures demonstrated their great potential for neural engineering and development of novel neural regenerative devices. Ministry of Education (MOE) Nanyang Technological University M.W. is grateful to the funding support by a start-up grant of Nanyang Assistant Professorship (M4080992) from Nanyang Technological University and AcRF Tier 2 (ARC 36/13: M4020172) from the Ministry of Education, Singapore. 2021-07-23T10:31:55Z 2021-07-23T10:31:55Z 2019 Journal Article Wu, Y., Peng, Y., Bohra, H., Zou, J., Ranjan, V. D., Zhang, Y., Zhang, Q. & Wang, M. (2019). Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells. ACS Applied Materials and Interfaces, 11(5), 4833-4841. https://dx.doi.org/10.1021/acsami.8b19631 1944-8244 0000-0002-5694-8699 0000-0002-6445-6854 https://hdl.handle.net/10356/151247 10.1021/acsami.8b19631 30624894 2-s2.0-85060577594 5 11 4833 4841 en M4080992 ARC 36/13: M4020172 ACS Applied Materials and Interfaces © 2019 American Chemical Society. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Polymers Semiconductors Wu, Yingjie Peng, Yanfen Bohra, Hassan Zou, Jianping Ranjan, Vivek Damodar Zhang, Yilei Zhang, Qing Wang, Mingfeng Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title | Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title_full | Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title_fullStr | Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title_full_unstemmed | Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title_short | Photoconductive micro/nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron-like cells |
| title_sort | photoconductive micro nanoscale interfaces of a semiconducting polymer for wireless stimulation of neuron like cells |
| topic | Engineering::Chemical engineering Polymers Semiconductors |
| url | https://hdl.handle.net/10356/151247 |
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