Biofilm-associated infection by enterococci
Enterococci are ubiquitous members of the human gut microbiota and frequent causes of biofilm-associated opportunistic infections. Enterococci cause 25% of all catheter-associated urinary tract infections, are frequently isolated in wounds and are increasingly found in infective endocarditis, and al...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/151331 |
| _version_ | 1826124136429125632 |
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| author | Ch'ng, Jun-Hong Chong, Kelvin Kian Long Lam, Ling Ning Wong, Jun Jie Kline, Kimberly A. |
| author2 | Interdisciplinary Graduate School (IGS) |
| author_facet | Interdisciplinary Graduate School (IGS) Ch'ng, Jun-Hong Chong, Kelvin Kian Long Lam, Ling Ning Wong, Jun Jie Kline, Kimberly A. |
| author_sort | Ch'ng, Jun-Hong |
| collection | NTU |
| description | Enterococci are ubiquitous members of the human gut microbiota and frequent causes of biofilm-associated opportunistic infections. Enterococci cause 25% of all catheter-associated urinary tract infections, are frequently isolated in wounds and are increasingly found in infective endocarditis, and all of these infections are associated with biofilms. Enterococcal biofilms are intrinsically tolerant to antimicrobials and thus are a serious impediment for treating infections. In this Review, we describe the spatiotemporal development of enterococcal biofilms and the factors that promote or inhibit biofilm formation. We discuss how the environment, including the host and other co-colonizing microorganisms, affects biofilm development. Finally, we provide an overview of current and future interventions to limit enterococcal biofilm-associated infections. Overall, enterococcal biofilms remain a pressing clinical problem, and there is an urgent need to better understand their development and persistence and to identify novel treatments. |
| first_indexed | 2024-10-01T06:15:44Z |
| format | Journal Article |
| id | ntu-10356/151331 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:15:44Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1513312021-06-22T06:14:22Z Biofilm-associated infection by enterococci Ch'ng, Jun-Hong Chong, Kelvin Kian Long Lam, Ling Ning Wong, Jun Jie Kline, Kimberly A. Interdisciplinary Graduate School (IGS) School of Biological Sciences Singapore Centre for Environmental Life Sciences and Engineering NTU Institute for Health Technologies Engineering::Environmental engineering Antimicrobial Resistance Bacterial Pathogenesis Enterococci are ubiquitous members of the human gut microbiota and frequent causes of biofilm-associated opportunistic infections. Enterococci cause 25% of all catheter-associated urinary tract infections, are frequently isolated in wounds and are increasingly found in infective endocarditis, and all of these infections are associated with biofilms. Enterococcal biofilms are intrinsically tolerant to antimicrobials and thus are a serious impediment for treating infections. In this Review, we describe the spatiotemporal development of enterococcal biofilms and the factors that promote or inhibit biofilm formation. We discuss how the environment, including the host and other co-colonizing microorganisms, affects biofilm development. Finally, we provide an overview of current and future interventions to limit enterococcal biofilm-associated infections. Overall, enterococcal biofilms remain a pressing clinical problem, and there is an urgent need to better understand their development and persistence and to identify novel treatments. Ministry of Education (MOE) Work in the Kline laboratory related to this article is supported by the Ministry of Education Singapore under its Research Centre of Excellence Program and by the Ministry of Education Singapore under its Tier 2 programme (MOE2014-T2-2-124) and the National Institutes of Health (NIH; 1 R21 AI126023-01). 2021-06-22T06:14:22Z 2021-06-22T06:14:22Z 2019 Journal Article Ch'ng, J., Chong, K. K. L., Lam, L. N., Wong, J. J. & Kline, K. A. (2019). Biofilm-associated infection by enterococci. Nature Reviews Microbiology, 17(2), 82-94. https://dx.doi.org/10.1038/s41579-018-0107-z 1740-1526 0000-0002-5472-3074 https://hdl.handle.net/10356/151331 10.1038/s41579-018-0107-z 30337708 2-s2.0-85055356351 2 17 82 94 en MOE2014-T2-2-124 Nature Reviews Microbiology © 2018 Springer Nature Limited. All rights reserved. |
| spellingShingle | Engineering::Environmental engineering Antimicrobial Resistance Bacterial Pathogenesis Ch'ng, Jun-Hong Chong, Kelvin Kian Long Lam, Ling Ning Wong, Jun Jie Kline, Kimberly A. Biofilm-associated infection by enterococci |
| title | Biofilm-associated infection by enterococci |
| title_full | Biofilm-associated infection by enterococci |
| title_fullStr | Biofilm-associated infection by enterococci |
| title_full_unstemmed | Biofilm-associated infection by enterococci |
| title_short | Biofilm-associated infection by enterococci |
| title_sort | biofilm associated infection by enterococci |
| topic | Engineering::Environmental engineering Antimicrobial Resistance Bacterial Pathogenesis |
| url | https://hdl.handle.net/10356/151331 |
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