Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases
The progressive loss of structure and function of neurons causes various neurodegenerative diseases which need to be examined using measurable indicators, known as biomarkers. Proteins are the building blocks for the cell and are essential as they participate in many processes in the cells. When bio...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/151351 |
| _version_ | 1826124058004029440 |
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| author | Kumar, Sundramurthy Karthikeyan, Narayanan Mishra, Sachin Padmanabhan, Parasuraman Radda, George Gulyás, Balázs |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Kumar, Sundramurthy Karthikeyan, Narayanan Mishra, Sachin Padmanabhan, Parasuraman Radda, George Gulyás, Balázs |
| author_sort | Kumar, Sundramurthy |
| collection | NTU |
| description | The progressive loss of structure and function of neurons causes various neurodegenerative diseases which need to be examined using measurable indicators, known as biomarkers. Proteins are the building blocks for the cell and are essential as they participate in many processes in the cells. When biologically essential proteins are impaired, it leads to devastating consequences in humans and mammals among which the most prominent is neurodegenerative disease. Proteins conform to three-dimensional structures to enable their functions. Besides, some proteins have the tendency to form self-assembly structures. When these self-assembly proteins assume abnormal conformation, they accumulate and cause pathological conditions. The genetic and molecular origins of protein misfolding in association with their relationship with neurodegeneration and aging are being studied to better understand and develop treatments. Accumulations of these misfolded proteins form aggregates which is considered as the most prominent cause of many neurodegenerative diseases. This article reviews the misfolded proteins in various neurodegenerative diseases and analyzes the diverse aspects of protein misfolding as a potential agent of biomarkers with an approach for finding an inhibitor for misfolding. |
| first_indexed | 2024-10-01T06:14:27Z |
| format | Journal Article |
| id | ntu-10356/151351 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:14:27Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1513512021-06-22T09:41:25Z Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases Kumar, Sundramurthy Karthikeyan, Narayanan Mishra, Sachin Padmanabhan, Parasuraman Radda, George Gulyás, Balázs Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Misfolded Protein Neurodegenerative Diseases The progressive loss of structure and function of neurons causes various neurodegenerative diseases which need to be examined using measurable indicators, known as biomarkers. Proteins are the building blocks for the cell and are essential as they participate in many processes in the cells. When biologically essential proteins are impaired, it leads to devastating consequences in humans and mammals among which the most prominent is neurodegenerative disease. Proteins conform to three-dimensional structures to enable their functions. Besides, some proteins have the tendency to form self-assembly structures. When these self-assembly proteins assume abnormal conformation, they accumulate and cause pathological conditions. The genetic and molecular origins of protein misfolding in association with their relationship with neurodegeneration and aging are being studied to better understand and develop treatments. Accumulations of these misfolded proteins form aggregates which is considered as the most prominent cause of many neurodegenerative diseases. This article reviews the misfolded proteins in various neurodegenerative diseases and analyzes the diverse aspects of protein misfolding as a potential agent of biomarkers with an approach for finding an inhibitor for misfolding. Agency for Science, Technology and Research (A*STAR) Nanyang Technological University Author SK, PP, and BG like to acknowledge the support from Lee Kong Chian School of Medicine, Nanyang Technological University Start-Up Grant. KN likes to thank Institute of Bioengineering and Nanotechnology, Singapore, for funding. We would like to thank Ms. Suzanne Danley (Department of Orthopedics, West Virginia University) for editing the manuscript. 2021-06-22T09:41:25Z 2021-06-22T09:41:25Z 2019 Journal Article Kumar, S., Karthikeyan, N., Mishra, S., Padmanabhan, P., Radda, G. & Gulyás, B. (2019). Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases. Molecular Neurobiology, 56(4), 2559-2578. https://dx.doi.org/10.1007/s12035-018-1232-4 0893-7648 0000-0001-5136-2296 https://hdl.handle.net/10356/151351 10.1007/s12035-018-1232-4 30043261 2-s2.0-85050638955 4 56 2559 2578 en Molecular Neurobiology © 2018 Springer Science Business Media, LLC, part of Springer Nature. All rights reserved. |
| spellingShingle | Science::Medicine Misfolded Protein Neurodegenerative Diseases Kumar, Sundramurthy Karthikeyan, Narayanan Mishra, Sachin Padmanabhan, Parasuraman Radda, George Gulyás, Balázs Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title | Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title_full | Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title_fullStr | Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title_full_unstemmed | Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title_short | Misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| title_sort | misfolded protein linked strategies toward biomarker development for neurodegenerative diseases |
| topic | Science::Medicine Misfolded Protein Neurodegenerative Diseases |
| url | https://hdl.handle.net/10356/151351 |
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