MRI-compatible pneumatic stimulator for sensorimotor mapping
Background: Two major concerns with respect to task-based motor functional magnetic resonance imaging (fMRI) are inadequate participants’ performance as well as intra- and inter-subject variability in execution of the motor action. New method: This study validates the use of an MRI-compatible stimul...
| Autors principals: | , , , , , , , |
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| Format: | Journal Article |
| Idioma: | English |
| Publicat: |
2021
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| Accés en línia: | https://hdl.handle.net/10356/151416 |
| _version_ | 1826116399322365952 |
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| author | Lolli, Valentina Rovai, Antonin Trotta, Nicola Bourguignon, Mathieu Goldman, Serge Sadeghi, Niloufar Jousmäki, Veikko De Tiège, Xavier |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Lolli, Valentina Rovai, Antonin Trotta, Nicola Bourguignon, Mathieu Goldman, Serge Sadeghi, Niloufar Jousmäki, Veikko De Tiège, Xavier |
| author_sort | Lolli, Valentina |
| collection | NTU |
| description | Background: Two major concerns with respect to task-based motor functional magnetic resonance imaging (fMRI) are inadequate participants’ performance as well as intra- and inter-subject variability in execution of the motor action. New method: This study validates the use of an MRI-compatible stimulator based on a pneumatic artificial muscle (PAM) for block-design fMRI mapping of the primary sensorimotor (SM1) cortex in a series of fifteen right-handed healthy subjects. The PAM stimulator elicits computer-controlled timely and reproducible passive movements of fingers/toes. Participants performed comparable active and passive PAM-induced flexion-extensions of the index fingers. Results: Passive movement of the right index finger and passive alternating right and left index finger movement resulted in a significant increase in blood-oxygen-level-dependent (BOLD) signal in contralateral SM1 cortex in 14/15 and 15/15 subjects respectively. Similar networks were recruited by active and passive index finger movements. However, at the group level, active movement induced significantly higher increases in BOLD signal than passive movement in contralateral SM1 cortex (p < 0.05 Family Wise Error [FWE] corrected), supplementary motor area (p < 0.001 uncorrected), ipsilateral cerebellum (p < 0.001 uncorrected), and bilateral putamina (p < 0.001 uncorrected). Comparison with existing method(s): As compared to the several MRI-compatible robotic devices for computer-controlled passive movement of the fingers that were introduced in the past decades, the proposed PAM-based stimulator is smaller, handier, and easier to use in the MRI setting. Conclusions: PAM-based stimulators can be reliably used for passive sensorimotor fMRI mapping in healthy subjects. Using this approach, bilateral SM1 cortices can be mapped accurately during a single 6-min block-design fMRI protocol. |
| first_indexed | 2024-10-01T04:10:47Z |
| format | Journal Article |
| id | ntu-10356/151416 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:10:47Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1514162021-06-24T05:05:30Z MRI-compatible pneumatic stimulator for sensorimotor mapping Lolli, Valentina Rovai, Antonin Trotta, Nicola Bourguignon, Mathieu Goldman, Serge Sadeghi, Niloufar Jousmäki, Veikko De Tiège, Xavier Lee Kong Chian School of Medicine (LKCMedicine) Cognitive Neuroimaging Centre Science::Medicine Blood-oxygen-level-dependent Signal Functional Magnetic Resonance Imaging Background: Two major concerns with respect to task-based motor functional magnetic resonance imaging (fMRI) are inadequate participants’ performance as well as intra- and inter-subject variability in execution of the motor action. New method: This study validates the use of an MRI-compatible stimulator based on a pneumatic artificial muscle (PAM) for block-design fMRI mapping of the primary sensorimotor (SM1) cortex in a series of fifteen right-handed healthy subjects. The PAM stimulator elicits computer-controlled timely and reproducible passive movements of fingers/toes. Participants performed comparable active and passive PAM-induced flexion-extensions of the index fingers. Results: Passive movement of the right index finger and passive alternating right and left index finger movement resulted in a significant increase in blood-oxygen-level-dependent (BOLD) signal in contralateral SM1 cortex in 14/15 and 15/15 subjects respectively. Similar networks were recruited by active and passive index finger movements. However, at the group level, active movement induced significantly higher increases in BOLD signal than passive movement in contralateral SM1 cortex (p < 0.05 Family Wise Error [FWE] corrected), supplementary motor area (p < 0.001 uncorrected), ipsilateral cerebellum (p < 0.001 uncorrected), and bilateral putamina (p < 0.001 uncorrected). Comparison with existing method(s): As compared to the several MRI-compatible robotic devices for computer-controlled passive movement of the fingers that were introduced in the past decades, the proposed PAM-based stimulator is smaller, handier, and easier to use in the MRI setting. Conclusions: PAM-based stimulators can be reliably used for passive sensorimotor fMRI mapping in healthy subjects. Using this approach, bilateral SM1 cortices can be mapped accurately during a single 6-min block-design fMRI protocol. 2021-06-24T05:05:30Z 2021-06-24T05:05:30Z 2019 Journal Article Lolli, V., Rovai, A., Trotta, N., Bourguignon, M., Goldman, S., Sadeghi, N., Jousmäki, V. & De Tiège, X. (2019). MRI-compatible pneumatic stimulator for sensorimotor mapping. Journal of Neuroscience Methods, 313, 29-36. https://dx.doi.org/10.1016/j.jneumeth.2018.12.014 0165-0270 0000-0002-5555-1745 0000-0003-1694-5087 https://hdl.handle.net/10356/151416 10.1016/j.jneumeth.2018.12.014 30578869 2-s2.0-85059154817 313 29 36 en Journal of Neuroscience Methods © 2018 Elsevier B.V. All rights reserved. |
| spellingShingle | Science::Medicine Blood-oxygen-level-dependent Signal Functional Magnetic Resonance Imaging Lolli, Valentina Rovai, Antonin Trotta, Nicola Bourguignon, Mathieu Goldman, Serge Sadeghi, Niloufar Jousmäki, Veikko De Tiège, Xavier MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title | MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title_full | MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title_fullStr | MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title_full_unstemmed | MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title_short | MRI-compatible pneumatic stimulator for sensorimotor mapping |
| title_sort | mri compatible pneumatic stimulator for sensorimotor mapping |
| topic | Science::Medicine Blood-oxygen-level-dependent Signal Functional Magnetic Resonance Imaging |
| url | https://hdl.handle.net/10356/151416 |
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