A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) is a key Ras activator that is autoinhibited in the cytosol and activates upon membrane recruitment. Autoinhibition release involves structural rearrangements of the protein at the membrane and thus introduces a delay between initia...

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Bibliographic Details
Main Authors: Huang, William Y. C., Alvarez, Steven, Kondo, Yasushi, Lee, Young Kwang, Chung, Jean K., Lam, Hiu Yue Monatrice, Biswas, Kabir Hassan, Kuriyan, John, Groves, Jay T.
Other Authors: School of Materials Science and Engineering
Format: Journal Article
Language:English
Published: 2021
Subjects:
Engineering::Materials
Guanine-nucleotide Exchange
Single-molecule
Online Access:https://hdl.handle.net/10356/151598

Internet

https://hdl.handle.net/10356/151598

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