Diagnostic and prognostic value of circulating circRNAs in cancer
Cancer has been regarded as one of the leading causes of mortality worldwide. Diagnostic and prognostic biomarkers with high sensitivity and specificity for cancer play a crucial role in preventing or treating cancer. Circular RNAs (circRNAs), which hold great potential for the management of cancer...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/151753 |
| _version_ | 1811697289840820224 |
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| author | Wang, Mina Xie, Feiyu Lin, Jiaran Zhao, Yihan Zhang, Qian Liao, Zehuan Wei, Peng |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Wang, Mina Xie, Feiyu Lin, Jiaran Zhao, Yihan Zhang, Qian Liao, Zehuan Wei, Peng |
| author_sort | Wang, Mina |
| collection | NTU |
| description | Cancer has been regarded as one of the leading causes of mortality worldwide. Diagnostic and prognostic biomarkers with high sensitivity and specificity for cancer play a crucial role in preventing or treating cancer. Circular RNAs (circRNAs), which hold great potential for the management of cancer patients due to their abundance, stable property, and high specificity in serum, plasma, and other body fluids, can be used as non-invasive and blood-based biomarkers in cancer diagnosis and prognosis. There are four types of circRNAs including exonic circRNAs (ecircRNA), intronic circRNAs, exon-intron circRNAs (EIciRNA), and intergenic circRNAs. CircRNAs can act as miRNA sponges, affect protein translation, interplay with RNA binding proteins, regulate protein recruitment, and modulate protein scaffolding and assembly. Therefore, the multifunctionalities of circRNAs make them ideal for detecting and predicting cancer. Indeed, circRNAs manifest high sensitivity and specificity in more than ten types of cancer. This review aims to consolidate the types and functions of circRNAs, as well as discuss the diagnostic and prognostic value of circulating circRNAs in cancer. |
| first_indexed | 2024-10-01T07:52:54Z |
| format | Journal Article |
| id | ntu-10356/151753 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:52:54Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1517532023-02-28T17:07:04Z Diagnostic and prognostic value of circulating circRNAs in cancer Wang, Mina Xie, Feiyu Lin, Jiaran Zhao, Yihan Zhang, Qian Liao, Zehuan Wei, Peng School of Biological Sciences Science::Medicine CircRNA Circulation Cancer has been regarded as one of the leading causes of mortality worldwide. Diagnostic and prognostic biomarkers with high sensitivity and specificity for cancer play a crucial role in preventing or treating cancer. Circular RNAs (circRNAs), which hold great potential for the management of cancer patients due to their abundance, stable property, and high specificity in serum, plasma, and other body fluids, can be used as non-invasive and blood-based biomarkers in cancer diagnosis and prognosis. There are four types of circRNAs including exonic circRNAs (ecircRNA), intronic circRNAs, exon-intron circRNAs (EIciRNA), and intergenic circRNAs. CircRNAs can act as miRNA sponges, affect protein translation, interplay with RNA binding proteins, regulate protein recruitment, and modulate protein scaffolding and assembly. Therefore, the multifunctionalities of circRNAs make them ideal for detecting and predicting cancer. Indeed, circRNAs manifest high sensitivity and specificity in more than ten types of cancer. This review aims to consolidate the types and functions of circRNAs, as well as discuss the diagnostic and prognostic value of circulating circRNAs in cancer. Published version This work was funded by the National Natural Science Foundation of China (Grant No. 31800652), Young Scientist Program by Beijing University of Chinese Medicine (Grant No. BUCM-2019-QNKXJ-C014), and the Double First Class Construction Funds of Discipline of Integrated Traditional Chinese and Western Medicine of Beijing University of Chinese Medicine. 2021-07-15T08:50:27Z 2021-07-15T08:50:27Z 2021 Journal Article Wang, M., Xie, F., Lin, J., Zhao, Y., Zhang, Q., Liao, Z. & Wei, P. (2021). Diagnostic and prognostic value of circulating circRNAs in cancer. Frontiers in Medicine, 8, 649383-. https://dx.doi.org/10.3389/fmed.2021.649383 2296-858X https://hdl.handle.net/10356/151753 10.3389/fmed.2021.649383 33816529 2-s2.0-85103518494 8 649383 en Frontiers in Medicine © 2021 Wang, Xie, Lin, Zhao, Zhang, Liao and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine CircRNA Circulation Wang, Mina Xie, Feiyu Lin, Jiaran Zhao, Yihan Zhang, Qian Liao, Zehuan Wei, Peng Diagnostic and prognostic value of circulating circRNAs in cancer |
| title | Diagnostic and prognostic value of circulating circRNAs in cancer |
| title_full | Diagnostic and prognostic value of circulating circRNAs in cancer |
| title_fullStr | Diagnostic and prognostic value of circulating circRNAs in cancer |
| title_full_unstemmed | Diagnostic and prognostic value of circulating circRNAs in cancer |
| title_short | Diagnostic and prognostic value of circulating circRNAs in cancer |
| title_sort | diagnostic and prognostic value of circulating circrnas in cancer |
| topic | Science::Medicine CircRNA Circulation |
| url | https://hdl.handle.net/10356/151753 |
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