Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults
Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance...
| Principais autores: | , , , , , , |
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| Formato: | Journal Article |
| Idioma: | English |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://hdl.handle.net/10356/151754 |
| _version_ | 1826119726443528192 |
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| author | Tranæs, Kaare Ding, Cherlyn Chooi, Yu Chung Chan, Zhiling Choo, John Leow, Melvin Khee-Shing Magkos, Faidon |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tranæs, Kaare Ding, Cherlyn Chooi, Yu Chung Chan, Zhiling Choo, John Leow, Melvin Khee-Shing Magkos, Faidon |
| author_sort | Tranæs, Kaare |
| collection | NTU |
| description | Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism. |
| first_indexed | 2024-10-01T05:04:50Z |
| format | Journal Article |
| id | ntu-10356/151754 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:04:50Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1517542023-03-05T16:47:01Z Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults Tranæs, Kaare Ding, Cherlyn Chooi, Yu Chung Chan, Zhiling Choo, John Leow, Melvin Khee-Shing Magkos, Faidon Lee Kong Chian School of Medicine (LKCMedicine) Singapore Institute for Clinical Sciences, A*STAR Science::Medicine Insulin Resistance Lipoprotein Particle Size Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism. Agency for Science, Technology and Research (A*STAR) Published version Award BMSI/16-07803C-R20H (FM) from Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore. The sponsor had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. 2021-07-15T09:00:49Z 2021-07-15T09:00:49Z 2021 Journal Article Tranæs, K., Ding, C., Chooi, Y. C., Chan, Z., Choo, J., Leow, M. K. & Magkos, F. (2021). Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults. Frontiers in Nutrition, 8, 651199-. https://dx.doi.org/10.3389/fnut.2021.651199 2296-861X https://hdl.handle.net/10356/151754 10.3389/fnut.2021.651199 33718425 2-s2.0-85102472938 8 651199 en BMSI/16-07803C-R20H Frontiers in Nutrition © 2021 Tranæs, Ding, Chooi, Chan, Choo, Leow and Magkos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine Insulin Resistance Lipoprotein Particle Size Tranæs, Kaare Ding, Cherlyn Chooi, Yu Chung Chan, Zhiling Choo, John Leow, Melvin Khee-Shing Magkos, Faidon Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title | Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title_full | Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title_fullStr | Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title_full_unstemmed | Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title_short | Dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal-weight Chinese adults |
| title_sort | dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal weight chinese adults |
| topic | Science::Medicine Insulin Resistance Lipoprotein Particle Size |
| url | https://hdl.handle.net/10356/151754 |
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