Regional diets targeting gut microbial dynamics to support prolonged healthspan
In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to impro...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/151776 |
| _version_ | 1811691377942069248 |
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| author | Low, Dorrain Yanwen Hejndorf, Sophia Tharmabalan, Rachel Thomas Poppema, Sibrandes Pettersson, Sven |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Low, Dorrain Yanwen Hejndorf, Sophia Tharmabalan, Rachel Thomas Poppema, Sibrandes Pettersson, Sven |
| author_sort | Low, Dorrain Yanwen |
| collection | NTU |
| description | In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan. |
| first_indexed | 2024-10-01T06:18:56Z |
| format | Journal Article |
| id | ntu-10356/151776 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:18:56Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1517762023-03-05T16:48:29Z Regional diets targeting gut microbial dynamics to support prolonged healthspan Low, Dorrain Yanwen Hejndorf, Sophia Tharmabalan, Rachel Thomas Poppema, Sibrandes Pettersson, Sven Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Gut Microbiome Gut Microbiota In the last 150 years, we have seen a significant increase in average life expectancy, associated with a shift from infectious to non-communicable diseases. The rising incidence of these diseases, for which age is often the largest risk factor, highlights the need for contemporary societies to improve healthy ageing for their growing silver generations. As ageing is an inevitable, non-reversing and highly individualised process, we need to better understand how non-genetic factors like diet choices and commensal gut microbes can modulate the biology of ageing. In this review, we discuss how geographical and ethnic variations influence habitual dietary patterns, nutrient structure, and gut microbial profiles with potential impact on the human healthspan. Several gut microbial genera have been associated with healthy elderly populations but are highly variable across populations. It seems unlikely that a universal pro-longevity gut microbiome exists. Rather, the optimal microbiome appears to be conditional on the microbial functionality acting on regional- and ethnicity-specific trends driven by cultural food context. We also highlight dietary and microbial factors that have been observed to elicit individual and clustered biological responses. Finally, we identify next generation avenues to modify otherwise fixed host functions and the individual ageing trajectory by manipulating the malleable gut microbiome with regionally adapted, personalised food intervention regimens targeted at prolonging human healthspan. Nanyang Technological University Published version DL received the support of Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, through the award of the Presidential Postdoctoral Fellowship (Grant No. 001991-00001). 2021-07-16T10:06:37Z 2021-07-16T10:06:37Z 2021 Journal Article Low, D. Y., Hejndorf, S., Tharmabalan, R. T., Poppema, S. & Pettersson, S. (2021). Regional diets targeting gut microbial dynamics to support prolonged healthspan. Frontiers in Microbiology, 12, 659465-. https://dx.doi.org/10.3389/fmicb.2021.659465 1664-302X https://hdl.handle.net/10356/151776 10.3389/fmicb.2021.659465 33995322 2-s2.0-85105936250 12 659465 en 001991-00001 Frontiers in Microbiology © 2021 Low, Hejndorf, Tharmabalan, Poppema and Pettersson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Science::Medicine Gut Microbiome Gut Microbiota Low, Dorrain Yanwen Hejndorf, Sophia Tharmabalan, Rachel Thomas Poppema, Sibrandes Pettersson, Sven Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_full | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_fullStr | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_full_unstemmed | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_short | Regional diets targeting gut microbial dynamics to support prolonged healthspan |
| title_sort | regional diets targeting gut microbial dynamics to support prolonged healthspan |
| topic | Science::Medicine Gut Microbiome Gut Microbiota |
| url | https://hdl.handle.net/10356/151776 |
| work_keys_str_mv | AT lowdorrainyanwen regionaldietstargetinggutmicrobialdynamicstosupportprolongedhealthspan AT hejndorfsophia regionaldietstargetinggutmicrobialdynamicstosupportprolongedhealthspan AT tharmabalanrachelthomas regionaldietstargetinggutmicrobialdynamicstosupportprolongedhealthspan AT poppemasibrandes regionaldietstargetinggutmicrobialdynamicstosupportprolongedhealthspan AT petterssonsven regionaldietstargetinggutmicrobialdynamicstosupportprolongedhealthspan |