Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in mycobacterium tuberculosis

Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in mycobacterium tuberculosis

Show other versions (1)

In response to the stress of infection, Mycobacterium tuberculosis (Mtb) reprograms its metabolism to accommodate nutrient and energetic demands in a changing environment. Pyruvate kinase (PYK) is an essential glycolytic enzyme in the phosphoenolpyruvate-pyruvate-oxaloacetate node that is a central...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Zhong, Wenhe, Guo, Jingjing, Cui, Liang, Chionh, Yok Hian, Li, Kuohan, El Sahili, Abbas, Cai, Qixu, Yuan, Meng, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Mu, Yuguang, Lescar, Julien, Dedon, Peter C.
מחברים אחרים:	School of Biological Sciences
פורמט:	Journal Article
שפה:	English
יצא לאור:	2021
נושאים:	Science::Biological sciences Allosteric Regulation Structural Dynamics
גישה מקוונת:	https://hdl.handle.net/10356/151959

פריטים דומים

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis
מאת: Zhong, Wenhe, et al.
יצא לאור: (2020)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
מאת: Zhong, Wenhe, et al.
יצא לאור: (2018)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
מאת: Zhong, Wenhe, et al.
יצא לאור: (2018)

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow
מאת: Fukang She, et al.
יצא לאור: (2025-02-01)

Allosteric enzymes /
מאת: Herve, Guy
יצא לאור: (1989)

Prospects for the use of allosteric drugs in real-world clinical practice
מאת: I. R. Svechkareva, et al.
יצא לאור: (2023-12-01)

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy
מאת: Tjaša Goričan, et al.
יצא לאור: (2024-12-01)

Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
מאת: Kannan, Srinivasaraghavan, et al.
יצא לאור: (2018)

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery
מאת: Xin Qiao, et al.
יצא לאור: (2025-02-01)

Defining neutralization and allostery by antibodies against COVID-19 variants
מאת: Tulsian, Nikhil Kumar, et al.
יצא לאור: (2024)

Degrons in Protein Substrates Program the Speed and Operating Efficiency of the AAA+ Lon Proteolytic Machine
מאת: Gur, Eyal, et al.
יצא לאור: (2010)

Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions : implications for fragment-based drug design
מאת: Chandramohan, Arun, et al.
יצא לאור: (2018)

An allosteric mechanism for potent inhibition of SARS-CoV-2 main proteinase
מאת: Zhang, Yunju, et al.
יצא לאור: (2024)

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites
מאת: Kumar, Ammu Prasanna, et al.
יצא לאור: (2020)

Conceptual Reconstruction and Epistemic Import: Allosteric Mechanistic Explanations as a Unified Theory-Net
מאת: Karina Alleva, et al.
יצא לאור: (2017-11-01)

Molecular Dynamics-Assisted Discovery of Novel Phosphodiesterase-5 Inhibitors Targeting a Unique Allosteric Pocket
מאת: Weihao Luo, et al.
יצא לאור: (2025-01-01)

Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility
מאת: Esra Ayan
יצא לאור: (2025-03-01)

Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor
מאת: Santiago Stabile, et al.
יצא לאור: (2023-11-01)

NADP(H) allosterically regulates the interaction between ferredoxin and ferredoxin‐NADP+ reductase
מאת: Yoko Kimata‐Ariga, et al.
יצא לאור: (2019-12-01)

Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters
מאת: Gilles Curien, et al.
יצא לאור: (2009-05-01)

Carbonylation is a hallmark of oxidative stress induced by lipid peroxidation products, 4-hydroxy-2-nonenal and 4-hydroxy-2- hexenal, on insulin signalling in L6 myoblasts.
מאת: Chionh, Yok Hian.
יצא לאור: (2009)

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection
מאת: Alabaf, S
יצא לאור: (2024)

(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter
מאת: Yingyao Wu, et al.
יצא לאור: (2024-12-01)

Imidazole Headgroup Phospholipid Shows Asymmetric Distribution in Vesicles and Zinc-Dependent Esterase Activity
מאת: Gabriela Sachet-Fernandez, et al.
יצא לאור: (2024-10-01)

Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-δ
מאת: Haiying Zhang, et al.
יצא לאור: (2024-12-01)

Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
מאת: Fabian Fröhlich, et al.
יצא לאור: (2023-01-01)

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase
מאת: Elisa Rojas-Prats, et al.
יצא לאור: (2024-12-01)

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide
מאת: César O. Lara, et al.
יצא לאור: (2025-02-01)

MEF-AlloSite: an accurate and robust Multimodel Ensemble Feature selection for the Allosteric Site identification model
מאת: Sadettin Y. Ugurlu, et al.
יצא לאור: (2024-10-01)

Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
מאת: Chunqiong Li, et al.
יצא לאור: (2024-12-01)

Purinergic Receptor (P2X7R): A Promising Anti-Parkinson’s Drug Target
מאת: Saivarshini Magham, et al.
יצא לאור: (2024-12-01)

Progress in GABAA receptor agonists for insomnia disorder
מאת: Weiyi Wang, et al.
יצא לאור: (2024-11-01)

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides
מאת: Hia, Fabian, et al.
יצא לאור: (2015)

The oxidative pentose phosphate pathway: structure and organisation.
מאת: Kruger, N, et al.
יצא לאור: (2003)

Microbial pentose utilization : current applications in biotechnology /
מאת: 443615 Ajay Singh, et al.
יצא לאור: (1995)

Identification of N[superscript 6],N[superscript 6]-Dimethyladenosine in Transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin
מאת: Chan, Tsz Yan Clement, et al.
יצא לאור: (2014)

Identifying Allosteric Small-Molecule Binding Sites of Inactive NS2B-NS3 Proteases of Pathogenic <i>Flaviviridae</i>
מאת: Hovakim Grabski, et al.
יצא לאור: (2024-12-01)

Small molecule protein assembly modulators with pan-cancer therapeutic efficacy
מאת: Anuradha F. Lingappa, et al.
יצא לאור: (2024-12-01)

Demystifying the Antidepressant Mechanism of Action of Stinels, a Novel Class of Neuroplastogens: Positive Allosteric Modulators of the NMDA Receptor
מאת: John E. Donello, et al.
יצא לאור: (2025-01-01)

Τhiazolidine-4-One Derivatives with Variable Modes of Inhibitory Action Against DPP4, a Drug Target with Multiple Activities and Established Role in Diabetes Mellitus Type II
מאת: Dionysia Amanatidou, et al.
יצא לאור: (2025-01-01)