Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in mycobacterium tuberculosis

Pyruvate kinase regulates the pentose-phosphate pathway in response to hypoxia in mycobacterium tuberculosis

Show other versions (1)

In response to the stress of infection, Mycobacterium tuberculosis (Mtb) reprograms its metabolism to accommodate nutrient and energetic demands in a changing environment. Pyruvate kinase (PYK) is an essential glycolytic enzyme in the phosphoenolpyruvate-pyruvate-oxaloacetate node that is a central...

书目详细资料
Main Authors:	Zhong, Wenhe, Guo, Jingjing, Cui, Liang, Chionh, Yok Hian, Li, Kuohan, El Sahili, Abbas, Cai, Qixu, Yuan, Meng, Michels, Paul A. M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D., Mu, Yuguang, Lescar, Julien, Dedon, Peter C.
其他作者:	School of Biological Sciences
格式:	Journal Article
语言:	English
出版:	2021
主题:	Science::Biological sciences Allosteric Regulation Structural Dynamics
在线阅读:	https://hdl.handle.net/10356/151959

相似书籍

Pyruvate Kinase Regulates the Pentose-Phosphate Pathway in Response to Hypoxia in Mycobacterium tuberculosis
由: Zhong, Wenhe, et al.
出版: (2020)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
由: Zhong, Wenhe, et al.
出版: (2018)

Allosteric pyruvate kinase-based “logic gate” synergistically senses energy and sugar levels in Mycobacterium tuberculosis
由: Zhong, Wenhe, et al.
出版: (2018)

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow
由: Fukang She, et al.
出版: (2025-02-01)

Allosteric enzymes /
由: Herve, Guy
出版: (1989)

Prospects for the use of allosteric drugs in real-world clinical practice
由: I. R. Svechkareva, et al.
出版: (2023-12-01)

Insights into the Allosteric Regulation of Human Hsp90 Revealed by NMR Spectroscopy
由: Tjaša Goričan, et al.
出版: (2024-12-01)

Defining neutralization and allostery by antibodies against COVID-19 variants
由: Tulsian, Nikhil Kumar, et al.
出版: (2024)

Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
由: Kannan, Srinivasaraghavan, et al.
出版: (2018)

Targeting cryptic allosteric sites of G protein-coupled receptors as a novel strategy for biased drug discovery
由: Xin Qiao, et al.
出版: (2025-02-01)

Degrons in Protein Substrates Program the Speed and Operating Efficiency of the AAA+ Lon Proteolytic Machine
由: Gur, Eyal, et al.
出版: (2010)

Predicting allosteric effects from orthosteric binding in Hsp90-ligand interactions : implications for fragment-based drug design
由: Chandramohan, Arun, et al.
出版: (2018)

Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain
由: Eva M García-Cuesta, et al.
出版: (2024-09-01)

Structural analysis of protein tyrosine phosphatase 1B reveals potentially druggable allosteric binding sites
由: Kumar, Ammu Prasanna, et al.
出版: (2020)

Conceptual Reconstruction and Epistemic Import: Allosteric Mechanistic Explanations as a Unified Theory-Net
由: Karina Alleva, et al.
出版: (2017-11-01)

Molecular Dynamics-Assisted Discovery of Novel Phosphodiesterase-5 Inhibitors Targeting a Unique Allosteric Pocket
由: Weihao Luo, et al.
出版: (2025-01-01)

Schild Analysis of the Interaction between Parthenolide and Cocaine Suggests an Allosteric Relationship for Their Effects on Planarian Motility
由: Jyothi Kakuturu, et al.
出版: (2024-09-01)

Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one
由: Yanmei Luo, et al.
出版: (2023-12-01)

Computational insights into the allosteric behavior of mini proinsulin driven by C peptide mobility
由: Esra Ayan
出版: (2025-03-01)

Design, Synthesis, and Biological Assessment of Novel Vanillin-Isoxazole Derivatives as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptor
由: Santiago Stabile, et al.
出版: (2023-11-01)

NADP(H) allosterically regulates the interaction between ferredoxin and ferredoxin‐NADP+ reductase
由: Yoko Kimata‐Ariga, et al.
出版: (2019-12-01)

Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters
由: Gilles Curien, et al.
出版: (2009-05-01)

Structure-activity exploration of a small-molecule allosteric inhibitor of T790M/L858R double mutant EGFR
由: Francesca Foschi, et al.
出版: (2023-12-01)

An allosteric mechanism for potent inhibition of SARS-CoV-2 main proteinase
由: Zhang, Yunju, et al.
出版: (2024)

Carbonylation is a hallmark of oxidative stress induced by lipid peroxidation products, 4-hydroxy-2-nonenal and 4-hydroxy-2- hexenal, on insulin signalling in L6 myoblasts.
由: Chionh, Yok Hian.
出版: (2009)

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection
由: Alabaf, S
出版: (2024)

(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter
由: Yingyao Wu, et al.
出版: (2024-12-01)

Imidazole Headgroup Phospholipid Shows Asymmetric Distribution in Vesicles and Zinc-Dependent Esterase Activity
由: Gabriela Sachet-Fernandez, et al.
出版: (2024-10-01)

Schaftoside improves HFpEF through regulation the autophagy-lysosome pathway by allosterically targeting CaMKII-δ
由: Haiying Zhang, et al.
出版: (2024-12-01)

Mechanistic model of MAPK signaling reveals how allostery and rewiring contribute to drug resistance
由: Fabian Fröhlich, et al.
出版: (2023-01-01)

Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor
由: Alexander O. Shpakov
出版: (2024-08-01)

Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase
由: Elisa Rojas-Prats, et al.
出版: (2024-12-01)

Allosteric modulation and direct activation of glycine receptors by a tricyclic sulfonamide
由: César O. Lara, et al.
出版: (2025-02-01)

MEF-AlloSite: an accurate and robust Multimodel Ensemble Feature selection for the Allosteric Site identification model
由: Sadettin Y. Ugurlu, et al.
出版: (2024-10-01)

Dengue Virus Non-Structural Protein 5
由: El Sahili, Abbas, et al.
出版: (2018)

Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides
由: Hia, Fabian, et al.
出版: (2015)

The oxidative pentose phosphate pathway: structure and organisation.
由: Kruger, N, et al.
出版: (2003)

Microbial pentose utilization : current applications in biotechnology /
由: 443615 Ajay Singh, et al.
出版: (1995)

Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation
由: Chunqiong Li, et al.
出版: (2024-12-01)

Purinergic Receptor (P2X7R): A Promising Anti-Parkinson’s Drug Target
由: Saivarshini Magham, et al.
出版: (2024-12-01)