Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation
Nano-layered solid-contact potassium-selective electrodes (K⁺-ISEs) were explored as model ion-selective electrodes for their practical use in clinical analysis. The ultra-thin ISEs ought to be manufactured in a highly reproducible manner, potentially making them suitable for mass production. Thus,...
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| Format: | Journal Article |
| Sprog: | English |
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2021
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| Online adgang: | https://hdl.handle.net/10356/152051 |
| _version_ | 1826110206845648896 |
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| author | Krikstolaityte, Vida Ding, Ruiyu Ruzgas, Tautgirdas Björklund, Sebastian Lisak, Grzegorz |
| author2 | School of Civil and Environmental Engineering |
| author_facet | School of Civil and Environmental Engineering Krikstolaityte, Vida Ding, Ruiyu Ruzgas, Tautgirdas Björklund, Sebastian Lisak, Grzegorz |
| author_sort | Krikstolaityte, Vida |
| collection | NTU |
| description | Nano-layered solid-contact potassium-selective electrodes (K⁺-ISEs) were explored as model ion-selective electrodes for their practical use in clinical analysis. The ultra-thin ISEs ought to be manufactured in a highly reproducible manner, potentially making them suitable for mass production. Thus, their development is pivotal towards miniaturised sensors with simplified conditioning/calibration protocols for point-of-care diagnostics. To study nano-layered ISEs, the ultra-thin nature of ISEs for the first time enabled to combine potentiometry-quartz crystal microbalance with dissipation (QCM-D) to obtain value-added information on the ISE potentiometric response regarding their physical state such as mass/thickness/viscoelastic properties/structural homogeneity. Specifically, the studies were focused on real-time observations of the ISE potentiometric response in relation to changes of their physicochemical properties during the ISE preparation (conditioning) and operation (including biofouling conditions) to identify the occurring processes that may accordingly be critical for potential instability of the ISEs, impeding their practical application. The K⁺-ISEs were prepared on a QCM-D gold sensor by electrodepositing poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) layer serving as an ion-to-electron transducer subsequently covered by a spin-coated poly(vinyl chloride) based K⁺-ion selective membrane (K⁺-ISM). The studies demonstrated that the performance of the nano-layered design of K⁺-ISEs is detrimentally affected by such processes as water layer formation accordingly causing the instability of the electrode potential. The changes in the ISE physical state such mass/viscoelastic properties associated with water layer formation and origin of the potential instability was already observed at the ISE conditioning stage. The potential instability of nano-layered ISEs limits their practical applicability, indicating the need of new solutions in designing ISEs, for instance, exploiting new water-resistant materials and modifying preparation protocols. |
| first_indexed | 2024-10-01T02:30:37Z |
| format | Journal Article |
| id | ntu-10356/152051 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:30:37Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1520512021-08-02T07:46:43Z Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation Krikstolaityte, Vida Ding, Ruiyu Ruzgas, Tautgirdas Björklund, Sebastian Lisak, Grzegorz School of Civil and Environmental Engineering Nanyang Environment and Water Research Institute Energy Research Institute @ NTU (ERI@N) Engineering::Environmental engineering Potentiometry Quartz Crystal Microbalance with Dissipation Nano-layered solid-contact potassium-selective electrodes (K⁺-ISEs) were explored as model ion-selective electrodes for their practical use in clinical analysis. The ultra-thin ISEs ought to be manufactured in a highly reproducible manner, potentially making them suitable for mass production. Thus, their development is pivotal towards miniaturised sensors with simplified conditioning/calibration protocols for point-of-care diagnostics. To study nano-layered ISEs, the ultra-thin nature of ISEs for the first time enabled to combine potentiometry-quartz crystal microbalance with dissipation (QCM-D) to obtain value-added information on the ISE potentiometric response regarding their physical state such as mass/thickness/viscoelastic properties/structural homogeneity. Specifically, the studies were focused on real-time observations of the ISE potentiometric response in relation to changes of their physicochemical properties during the ISE preparation (conditioning) and operation (including biofouling conditions) to identify the occurring processes that may accordingly be critical for potential instability of the ISEs, impeding their practical application. The K⁺-ISEs were prepared on a QCM-D gold sensor by electrodepositing poly(3,4-ethylenedioxythiophene)-poly(styrene sulfonate) layer serving as an ion-to-electron transducer subsequently covered by a spin-coated poly(vinyl chloride) based K⁺-ion selective membrane (K⁺-ISM). The studies demonstrated that the performance of the nano-layered design of K⁺-ISEs is detrimentally affected by such processes as water layer formation accordingly causing the instability of the electrode potential. The changes in the ISE physical state such mass/viscoelastic properties associated with water layer formation and origin of the potential instability was already observed at the ISE conditioning stage. The potential instability of nano-layered ISEs limits their practical applicability, indicating the need of new solutions in designing ISEs, for instance, exploiting new water-resistant materials and modifying preparation protocols. Economic Development Board (EDB) Nanyang Technological University The authors would like to thank NEWRI (Nanyang Technological University) and Singapore’s Economic Development Board (EDB) for their financial support of this research. 2021-08-02T07:46:43Z 2021-08-02T07:46:43Z 2020 Journal Article Krikstolaityte, V., Ding, R., Ruzgas, T., Björklund, S. & Lisak, G. (2020). Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation. Analytica Chimica Acta, 1128, 19-30. https://dx.doi.org/10.1016/j.aca.2020.06.044 0003-2670 https://hdl.handle.net/10356/152051 10.1016/j.aca.2020.06.044 32825902 2-s2.0-85087993746 1128 19 30 en Analytica Chimica Acta © 2020 Elsevier B.V. All rights reserved. |
| spellingShingle | Engineering::Environmental engineering Potentiometry Quartz Crystal Microbalance with Dissipation Krikstolaityte, Vida Ding, Ruiyu Ruzgas, Tautgirdas Björklund, Sebastian Lisak, Grzegorz Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title | Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title_full | Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title_fullStr | Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title_full_unstemmed | Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title_short | Characterization of nano-layered solid-contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| title_sort | characterization of nano layered solid contact ion selective electrodes by simultaneous potentiometry and quartz crystal microbalance with dissipation |
| topic | Engineering::Environmental engineering Potentiometry Quartz Crystal Microbalance with Dissipation |
| url | https://hdl.handle.net/10356/152051 |
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