Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies
Polymer nanoparticles and microparticles have been used primarily for drug delivery. There is now growing interest in further developing polymer-based solid cavitation agents to also enhance ultrasound imaging. We previously reported on a facile method to produce hollow poly(lactic-co-glycolic acid)...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/152400 |
| _version_ | 1811685892599840768 |
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| author | Gupta, Ipshita Su, Xiaoqian Jonnalagadda, Umesh Sai Das, Dhiman Pramanik, Manojit Kwan, James J. |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Gupta, Ipshita Su, Xiaoqian Jonnalagadda, Umesh Sai Das, Dhiman Pramanik, Manojit Kwan, James J. |
| author_sort | Gupta, Ipshita |
| collection | NTU |
| description | Polymer nanoparticles and microparticles have been used primarily for drug delivery. There is now growing interest in further developing polymer-based solid cavitation agents to also enhance ultrasound imaging. We previously reported on a facile method to produce hollow poly(lactic-co-glycolic acid) (PLGA) microparticles with different diameters and degrees of porosity. Here, we investigate the cavitation response from these PLGA microparticles with both therapeutic and diagnostic ultrasound transducers. Interestingly, all formulations exhibited stable cavitation; larger porous and multicavity particles also provided inertial cavitation at elevated acoustic pressure amplitudes. These larger particles also achieved contrast enhancement comparable to that of commercially available ultrasound contrast agents, with a maximum recorded contrast-to-tissue ratio of 28 dB. Therefore, we found that multicavity PLGA microparticles respond to both therapeutic and diagnostic ultrasound and may be applied as a theranostic agent. |
| first_indexed | 2024-10-01T04:51:45Z |
| format | Journal Article |
| id | ntu-10356/152400 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:51:45Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1524002023-12-29T06:48:19Z Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies Gupta, Ipshita Su, Xiaoqian Jonnalagadda, Umesh Sai Das, Dhiman Pramanik, Manojit Kwan, James J. School of Chemical and Biomedical Engineering Engineering::Bioengineering Therapeutic Ultrasound Diagnostic Ultrasound Polymer nanoparticles and microparticles have been used primarily for drug delivery. There is now growing interest in further developing polymer-based solid cavitation agents to also enhance ultrasound imaging. We previously reported on a facile method to produce hollow poly(lactic-co-glycolic acid) (PLGA) microparticles with different diameters and degrees of porosity. Here, we investigate the cavitation response from these PLGA microparticles with both therapeutic and diagnostic ultrasound transducers. Interestingly, all formulations exhibited stable cavitation; larger porous and multicavity particles also provided inertial cavitation at elevated acoustic pressure amplitudes. These larger particles also achieved contrast enhancement comparable to that of commercially available ultrasound contrast agents, with a maximum recorded contrast-to-tissue ratio of 28 dB. Therefore, we found that multicavity PLGA microparticles respond to both therapeutic and diagnostic ultrasound and may be applied as a theranostic agent. Ministry of Education (MOE) Ministry of Health (MOH) National Medical Research Council (NMRC) Accepted version The authors acknowledge the support from the Ministry of Education in Singapore under the Tier 1 grant scheme (RG144/18, RG127/19). This research is supported by the Singapore Ministry of Health’s National Medical Research Council under NMRC/OFYIRG/0034/2017. 2021-09-02T08:10:55Z 2021-09-02T08:10:55Z 2021 Journal Article Gupta, I., Su, X., Jonnalagadda, U. S., Das, D., Pramanik, M. & Kwan, J. J. (2021). Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies. Ultrasound in Medicine and Biology, 47(7), 1844-1856. https://dx.doi.org/10.1016/j.ultrasmedbio.2021.02.012 0301-5629 https://hdl.handle.net/10356/152400 10.1016/j.ultrasmedbio.2021.02.012 33810888 2-s2.0-85103483455 7 47 1844 1856 en RG144/18 RG127/19 NMRC/OFYIRG/0034/2017 Ultrasound in Medicine and Biology © 2021 World Federation for Ultrasound in Medicine & Biology. All rights reserved. This paper was published by Elsevier in Ultrasound in Medicine and Biology and is made available with permission of World Federation for Ultrasound in Medicine & Biology. application/pdf |
| spellingShingle | Engineering::Bioengineering Therapeutic Ultrasound Diagnostic Ultrasound Gupta, Ipshita Su, Xiaoqian Jonnalagadda, Umesh Sai Das, Dhiman Pramanik, Manojit Kwan, James J. Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title | Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title_full | Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title_fullStr | Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title_full_unstemmed | Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title_short | Investigating the acoustic response and contrast enhancement of drug-loadable PLGA microparticles with various shapes and morphologies |
| title_sort | investigating the acoustic response and contrast enhancement of drug loadable plga microparticles with various shapes and morphologies |
| topic | Engineering::Bioengineering Therapeutic Ultrasound Diagnostic Ultrasound |
| url | https://hdl.handle.net/10356/152400 |
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