Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation
For site-specific diseases such as atherosclerosis, it is desirable to noninvasively and locally deliver therapeutics for extended periods of time. High-intensity focused ultrasound (HIFU) provides targeted drug delivery, yet remains unable to sustain delivery beyond the HIFU treatment time. Further...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/152403 |
| _version_ | 1826112081388109824 |
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| author | Su, Xiaoqian Rakshit, Moumita Das, Prativa Gupta, Ipshita Das, Dhiman Pramanik, Manojit Ng, Kee Woei Kwan, James |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Su, Xiaoqian Rakshit, Moumita Das, Prativa Gupta, Ipshita Das, Dhiman Pramanik, Manojit Ng, Kee Woei Kwan, James |
| author_sort | Su, Xiaoqian |
| collection | NTU |
| description | For site-specific diseases such as atherosclerosis, it is desirable to noninvasively and locally deliver therapeutics for extended periods of time. High-intensity focused ultrasound (HIFU) provides targeted drug delivery, yet remains unable to sustain delivery beyond the HIFU treatment time. Furthermore, methods to validate HIFU-enhanced drug delivery remain limited. In this study, we report on HIFU-targeted implantation of degradable drug-loaded sound-sensitive multicavity PLGA microparticles (mcPLGA MPs) as a theranostic agent for the treatment of arterial lesions. Once implanted into the targeted tissue, mcPLGA MPs eluted dexamethasone for several days, thereby reducing inflammatory markers linked to oxidized lipid uptake in a foam cell spheroid model. Furthermore, implanted mcPLGA MPs created hyperechoic regions on diagnostic ultrasound images, and thus noninvasively verified that the target region was treated with the theranostic agents. This novel and innovative multifunctional theranostic platform may serve as a promising candidate for noninvasive imaging and treatment for site-specific diseases such as atherosclerosis. |
| first_indexed | 2024-10-01T03:01:07Z |
| format | Journal Article |
| id | ntu-10356/152403 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:01:07Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1524032021-09-04T20:11:02Z Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation Su, Xiaoqian Rakshit, Moumita Das, Prativa Gupta, Ipshita Das, Dhiman Pramanik, Manojit Ng, Kee Woei Kwan, James School of Chemical and Biomedical Engineering School of Materials Science and Engineering Nanyang Environment and Water Research Institute Environmental Chemistry and Materials Centre Engineering::Bioengineering Therapeutic Ultrasound Ultrasound Contrast Enhancement For site-specific diseases such as atherosclerosis, it is desirable to noninvasively and locally deliver therapeutics for extended periods of time. High-intensity focused ultrasound (HIFU) provides targeted drug delivery, yet remains unable to sustain delivery beyond the HIFU treatment time. Furthermore, methods to validate HIFU-enhanced drug delivery remain limited. In this study, we report on HIFU-targeted implantation of degradable drug-loaded sound-sensitive multicavity PLGA microparticles (mcPLGA MPs) as a theranostic agent for the treatment of arterial lesions. Once implanted into the targeted tissue, mcPLGA MPs eluted dexamethasone for several days, thereby reducing inflammatory markers linked to oxidized lipid uptake in a foam cell spheroid model. Furthermore, implanted mcPLGA MPs created hyperechoic regions on diagnostic ultrasound images, and thus noninvasively verified that the target region was treated with the theranostic agents. This novel and innovative multifunctional theranostic platform may serve as a promising candidate for noninvasive imaging and treatment for site-specific diseases such as atherosclerosis. Ministry of Education (MOE) Ministry of Health (MOH) Nanyang Technological University National Medical Research Council (NMRC) Accepted version This research is supported by the Ministry of Education in Singapore under the Tier 1 grant scheme (RG144/18, RG127/ 19), the Singapore Ministry of Health’s National Medical Research Council under its NMRC/OFYIRG/0034/2017, and the NTU − Northwestern Institute for Nanomedicine (04INS000156C150). 2021-09-02T06:13:17Z 2021-09-02T06:13:17Z 2021 Journal Article Su, X., Rakshit, M., Das, P., Gupta, I., Das, D., Pramanik, M., Ng, K. W. & Kwan, J. (2021). Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation. ACS Applied Materials and Interfaces, 13(21), 24422-24430. https://dx.doi.org/10.1021/acsami.1c01161 1944-8244 https://hdl.handle.net/10356/152403 10.1021/acsami.1c01161 34019376 2-s2.0-85107711256 21 13 24422 24430 en RG144/18 RG127/ 19 NMRC/OFYIRG/0034/2017 04INS000156C150 ACS Applied Materials and Interfaces This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Materials and Interfaces, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsami.1c01161 application/pdf |
| spellingShingle | Engineering::Bioengineering Therapeutic Ultrasound Ultrasound Contrast Enhancement Su, Xiaoqian Rakshit, Moumita Das, Prativa Gupta, Ipshita Das, Dhiman Pramanik, Manojit Ng, Kee Woei Kwan, James Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title | Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title_full | Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title_fullStr | Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title_full_unstemmed | Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title_short | Ultrasonic implantation and imaging of sound-sensitive theranostic agents for the treatment of arterial inflammation |
| title_sort | ultrasonic implantation and imaging of sound sensitive theranostic agents for the treatment of arterial inflammation |
| topic | Engineering::Bioengineering Therapeutic Ultrasound Ultrasound Contrast Enhancement |
| url | https://hdl.handle.net/10356/152403 |
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