| Summary: | Topical approaches to oral diseases require frequent dosing due to limited wound
retention times. A mucoadhesive drug delivery platform is proposed for oral wound
sites with soft tissue adhesion capability of up to 7 days. Bacterial cellulose (BC) and
photoactivated carbene-based bioadhesives are combined to yield flexible film platform
for interfacing soft tissues in dynamic, wet environments. Structure-activity
relationships evaluate UV dose and hydration state with respect to adhesive strength
on soft tissue mimics. The bioadhesive composite has an adhesion strength ranging
from 7-17 kPa and duration exceeding 48 hours in wet conditions under sustained
shear forces, while other mucoadhesives based on hydrophilic macromolecules exhibit
adhesion strength of 0.5-5 kPa and last only a few hours. The work highlights the first
evaluation of BC composites for mucoadhesive treatments in the buccal cavity.
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