Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface
The formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer afte...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/152923 |
| _version_ | 1811691862658908160 |
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| author | Li, Yuanzhe Li, Xiang Hao, Yu Liu, Yang Dong, ZhiLi Li, Kexin |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Li, Yuanzhe Li, Xiang Hao, Yu Liu, Yang Dong, ZhiLi Li, Kexin |
| author_sort | Li, Yuanzhe |
| collection | NTU |
| description | The formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer after overcoming possible electrical barriers and go through two phases of attachments: reversible and irreversible. In the first, bacterial attachment to the surface is reversible and occurs quickly whilst the latter is permanent and takes place over a longer period of time. Upon reaching a certain density in the bacterial community, quorum sensing causes phenotypical changes leading to a loss in motility and the production of EPS. This position paper seeks to address the problem of bacterial adhesion and biofilm formation for the medical surfaces by comparing inhabiting physicochemical interactions and biological mechanisms. Several physiochemical methodologies (e.g. ultrasonication, alternating magnetic field and chemical surface coating) and utilizing biological mechanisms (e.g. quorum quenching and EPS degrading enzymes) were suggested. The possible strategical applications of each category were suggested and evaluated to a balanced position to possibly eliminate the adhesion and formation of biofilms on medical-context surfaces. |
| first_indexed | 2024-10-01T06:26:38Z |
| format | Journal Article |
| id | ntu-10356/152923 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:26:38Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1529232023-07-14T15:49:43Z Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface Li, Yuanzhe Li, Xiang Hao, Yu Liu, Yang Dong, ZhiLi Li, Kexin School of Materials Science and Engineering Engineering::Materials Biofilms Adhesion Medical-context Surface The formation of biofilms on medical-context surfaces gives the EPS embedded bacterial community protection and additional advantages that planktonic cells would not have such as increased antibiotic resistance and horizontal gene transfer. Bacterial cells tend to attach to a conditioning layer after overcoming possible electrical barriers and go through two phases of attachments: reversible and irreversible. In the first, bacterial attachment to the surface is reversible and occurs quickly whilst the latter is permanent and takes place over a longer period of time. Upon reaching a certain density in the bacterial community, quorum sensing causes phenotypical changes leading to a loss in motility and the production of EPS. This position paper seeks to address the problem of bacterial adhesion and biofilm formation for the medical surfaces by comparing inhabiting physicochemical interactions and biological mechanisms. Several physiochemical methodologies (e.g. ultrasonication, alternating magnetic field and chemical surface coating) and utilizing biological mechanisms (e.g. quorum quenching and EPS degrading enzymes) were suggested. The possible strategical applications of each category were suggested and evaluated to a balanced position to possibly eliminate the adhesion and formation of biofilms on medical-context surfaces. Ministry of Education (MOE) Published version This research was funded by MOE Academic Research Fund (AcRF) Tier 1 Project “Nanostructured Titania with tunable hydrophilic/ hydrophobic behavior and photocatalytic function for marine structure application”, Grant Call (Call 1/2018) _MSE (EP Code EP5P, Project ID 122018-T1-001-077), Ministry of Education (MOE), Singapore. 2021-10-21T04:34:27Z 2021-10-21T04:34:27Z 2021 Journal Article Li, Y., Li, X., Hao, Y., Liu, Y., Dong, Z. & Li, K. (2021). Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface. International Journal of Biological Sciences, 17(7), 1769-1781. https://dx.doi.org/10.7150/ijbs.59025 1449-2288 https://hdl.handle.net/10356/152923 10.7150/ijbs.59025 33994861 2-s2.0-85105951285 7 17 1769 1781 en Call 1/2018 EP Code EP5P 122018-T1-001-077 International Journal of Biological Sciences © 2021 The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. application/pdf |
| spellingShingle | Engineering::Materials Biofilms Adhesion Medical-context Surface Li, Yuanzhe Li, Xiang Hao, Yu Liu, Yang Dong, ZhiLi Li, Kexin Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title | Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title_full | Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title_fullStr | Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title_full_unstemmed | Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title_short | Biological and physiochemical methods of biofilm adhesion resistance control of medical-context surface |
| title_sort | biological and physiochemical methods of biofilm adhesion resistance control of medical context surface |
| topic | Engineering::Materials Biofilms Adhesion Medical-context Surface |
| url | https://hdl.handle.net/10356/152923 |
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