Factors influencing phagocytosis of malaria parasites : the story so far
There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regu...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/152927 |
| _version_ | 1811681476824006656 |
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| author | Chua, Caroline Lin Lin Ng, Ida May Jen Yap, Bryan Ju Min Teo, Andrew |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Chua, Caroline Lin Lin Ng, Ida May Jen Yap, Bryan Ju Min Teo, Andrew |
| author_sort | Chua, Caroline Lin Lin |
| collection | NTU |
| description | There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for parasite clearance. Functional studies have identified specific opsonins, particularly antibodies and distinct phagocyte sub-populations that are associated with clinical protection against malaria. In addition, cellular and molecular studies have enhanced the understanding of the immunological pathways and outcomes following phagocytosis of malaria parasites. In this review, an integrated view of the factors that can affect phagocytosis of infected erythrocytes and parasite components, the immunological consequences and their association with clinical protection against Plasmodium spp. infection is provided. Several red blood cell disorders and co-infections, and drugs that can influence phagocytic capability during malaria are also discussed. It is hoped that an enhanced understanding of this immunological process can benefit the design of new therapeutics and vaccines to combat this infectious disease. |
| first_indexed | 2024-10-01T03:41:33Z |
| format | Journal Article |
| id | ntu-10356/152927 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:41:33Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1529272023-03-05T16:45:35Z Factors influencing phagocytosis of malaria parasites : the story so far Chua, Caroline Lin Lin Ng, Ida May Jen Yap, Bryan Ju Min Teo, Andrew Lee Kong Chian School of Medicine (LKCMedicine) Science::Medicine Phagocytosis Opsonic There are seven known species of Plasmodium spp. that can infect humans. The human host can mount a complex network of immunological responses to fight infection and one of these immune functions is phagocytosis. Effective and timely phagocytosis of parasites, accompanied by the activation of a regulated inflammatory response, is beneficial for parasite clearance. Functional studies have identified specific opsonins, particularly antibodies and distinct phagocyte sub-populations that are associated with clinical protection against malaria. In addition, cellular and molecular studies have enhanced the understanding of the immunological pathways and outcomes following phagocytosis of malaria parasites. In this review, an integrated view of the factors that can affect phagocytosis of infected erythrocytes and parasite components, the immunological consequences and their association with clinical protection against Plasmodium spp. infection is provided. Several red blood cell disorders and co-infections, and drugs that can influence phagocytic capability during malaria are also discussed. It is hoped that an enhanced understanding of this immunological process can benefit the design of new therapeutics and vaccines to combat this infectious disease. Nanyang Technological University Published version CLLC received support from Ministry of Education (MOE) Fundamental Research Grant Scheme of Malaysia (FRGS/1/2015/SKK08/Taylor/03/2). BJMY is supported by Taylor’s University through its Taylor’s Research Scholarship Programme. AT is supported by Nanyang Technological University Research Scholarship Block Fellowship of Singapore and Lee Kong Chian School of Medicine, Nanyang Technological University Singapore Start-Up grant. 2021-10-21T05:30:27Z 2021-10-21T05:30:27Z 2021 Journal Article Chua, C. L. L., Ng, I. M. J., Yap, B. J. M. & Teo, A. (2021). Factors influencing phagocytosis of malaria parasites : the story so far. Malaria Journal, 20, 319-. https://dx.doi.org/10.1186/s12936-021-03849-1 1475-2875 https://hdl.handle.net/10356/152927 10.1186/s12936-021-03849-1 34271941 2-s2.0-85110445465 20 319 en Malaria Journal © The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativeco mmons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Science::Medicine Phagocytosis Opsonic Chua, Caroline Lin Lin Ng, Ida May Jen Yap, Bryan Ju Min Teo, Andrew Factors influencing phagocytosis of malaria parasites : the story so far |
| title | Factors influencing phagocytosis of malaria parasites : the story so far |
| title_full | Factors influencing phagocytosis of malaria parasites : the story so far |
| title_fullStr | Factors influencing phagocytosis of malaria parasites : the story so far |
| title_full_unstemmed | Factors influencing phagocytosis of malaria parasites : the story so far |
| title_short | Factors influencing phagocytosis of malaria parasites : the story so far |
| title_sort | factors influencing phagocytosis of malaria parasites the story so far |
| topic | Science::Medicine Phagocytosis Opsonic |
| url | https://hdl.handle.net/10356/152927 |
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