Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies
A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity follo...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2021
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| Online Access: | https://hdl.handle.net/10356/153154 |
| _version_ | 1826122960203677696 |
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| author | Kong, Jia Wen Lam, Zhiyong Chan, Kiat Hwa Ganguly, Rakesh Lee, Joey Jia-Ying Loo, Lit-Hsin Webster, Richard D. Wong, Zhen Xuan Leong, Weng Kee |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Kong, Jia Wen Lam, Zhiyong Chan, Kiat Hwa Ganguly, Rakesh Lee, Joey Jia-Ying Loo, Lit-Hsin Webster, Richard D. Wong, Zhen Xuan Leong, Weng Kee |
| author_sort | Kong, Jia Wen |
| collection | NTU |
| description | A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death. |
| first_indexed | 2024-10-01T05:56:48Z |
| format | Journal Article |
| id | ntu-10356/153154 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:56:48Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1531542023-02-28T19:59:43Z Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies Kong, Jia Wen Lam, Zhiyong Chan, Kiat Hwa Ganguly, Rakesh Lee, Joey Jia-Ying Loo, Lit-Hsin Webster, Richard D. Wong, Zhen Xuan Leong, Weng Kee School of Physical and Mathematical Sciences Science::Chemistry Metals Carbonyls Cells Cluster chemistry Toxicity A set of metal carbonyl cluster-boronic acid conjugates of the group VIII metals (Fe, Ru, and Os) were synthesized and their antiproliferative effects measured against two breast cancer cell lines (MCF-7 and MDA-MB-231) and a noncancerous breast epithelial (MCF-10A) cell line. The cytotoxicity followed the order Ru > Os > Fe for the MDA-MB-231 cells, although the latter two exhibited similar cytotoxicity against MCF-7 and MCF-10A cells. The osmium species {Os3(CO)10(μ-H)[μ-SC6H4-p-B(OH)2]} (2) could be chemically oxidized to its hydroxy analogue [Os3(CO)10(μ-H)(μ-SC6H4-p-OH)] (2-OH), which showed comparable cytotoxicity. Mode of action studies pointed to an apoptotic pathway for cell death. Ministry of Education (MOE) Nanyang Technological University Published version This work was supported by Nanyang Technological University and the Ministry of Education (Research grant no. RG121/18). 2021-11-12T08:03:32Z 2021-11-12T08:03:32Z 2021 Journal Article Kong, J. W., Lam, Z., Chan, K. H., Ganguly, R., Lee, J. J., Loo, L., Webster, R. D., Wong, Z. X. & Leong, W. K. (2021). Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies. ACS Omega, 6(43), 29045-29053. https://dx.doi.org/10.1021/acsomega.1c04116 2470-1343 https://hdl.handle.net/10356/153154 10.1021/acsomega.1c04116 43 6 29045 29053 en RG121/18 ACS Omega © 2021 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution License. application/pdf |
| spellingShingle | Science::Chemistry Metals Carbonyls Cells Cluster chemistry Toxicity Kong, Jia Wen Lam, Zhiyong Chan, Kiat Hwa Ganguly, Rakesh Lee, Joey Jia-Ying Loo, Lit-Hsin Webster, Richard D. Wong, Zhen Xuan Leong, Weng Kee Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title | Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title_full | Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title_fullStr | Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title_full_unstemmed | Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title_short | Group VIII metal carbonyl cluster-boronic acid conjugates : cytotoxicity and mode of action studies |
| title_sort | group viii metal carbonyl cluster boronic acid conjugates cytotoxicity and mode of action studies |
| topic | Science::Chemistry Metals Carbonyls Cells Cluster chemistry Toxicity |
| url | https://hdl.handle.net/10356/153154 |
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