New route to macrocycles : synthesis of macrocycle via McMurry coupling
Named after its discoverer, John McMurry, McMurry coupling involves reductive dimerization of carbonyl compounds to yield olefins on treatment with low-valent titanium reagent. In this project, this mechanism had been adopted in order to synthesize an interesting macrocycle molecule. A TiCl4/Zn re...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Final Year Project (FYP) |
| Language: | English |
| Published: |
2009
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10356/15321 |
| _version_ | 1811685705933389824 |
|---|---|
| author | Fan, Huiyi |
| author2 | Andrew Clive Grimsdale |
| author_facet | Andrew Clive Grimsdale Fan, Huiyi |
| author_sort | Fan, Huiyi |
| collection | NTU |
| description | Named after its discoverer, John McMurry, McMurry coupling involves reductive dimerization of carbonyl compounds to yield olefins on treatment with low-valent titanium reagent.
In this project, this mechanism had been adopted in order to synthesize an interesting macrocycle molecule. A TiCl4/Zn reagent system was employed. Isophthaloyl chloride had first undergone Friedel-Crafts acylation with octyl benzene. The diketone formed from acylation was the precursor for the McMurry coupling reaction. |
| first_indexed | 2024-10-01T04:48:47Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/15321 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:48:47Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/153212023-03-04T15:38:58Z New route to macrocycles : synthesis of macrocycle via McMurry coupling Fan, Huiyi Andrew Clive Grimsdale School of Materials Science and Engineering DRNTU::Science::Chemistry::Organic chemistry::Polymers Named after its discoverer, John McMurry, McMurry coupling involves reductive dimerization of carbonyl compounds to yield olefins on treatment with low-valent titanium reagent. In this project, this mechanism had been adopted in order to synthesize an interesting macrocycle molecule. A TiCl4/Zn reagent system was employed. Isophthaloyl chloride had first undergone Friedel-Crafts acylation with octyl benzene. The diketone formed from acylation was the precursor for the McMurry coupling reaction. Bachelor of Engineering (Materials Engineering) 2009-04-27T07:51:22Z 2009-04-27T07:51:22Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/15321 en 52 p. application/pdf |
| spellingShingle | DRNTU::Science::Chemistry::Organic chemistry::Polymers Fan, Huiyi New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title | New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title_full | New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title_fullStr | New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title_full_unstemmed | New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title_short | New route to macrocycles : synthesis of macrocycle via McMurry coupling |
| title_sort | new route to macrocycles synthesis of macrocycle via mcmurry coupling |
| topic | DRNTU::Science::Chemistry::Organic chemistry::Polymers |
| url | http://hdl.handle.net/10356/15321 |
| work_keys_str_mv | AT fanhuiyi newroutetomacrocyclessynthesisofmacrocycleviamcmurrycoupling |