The genetic dissection of trisomy 21 and partial trisomy 21 cellular pathologies using induced pluripotent stem cells

The genetic dissection of trisomy 21 and partial trisomy 21 cellular pathologies using induced pluripotent stem cells

Introduction: Down Syndrome (DS), caused by full or partial trisomy of chromosome 21 (T21 or pT21) presents with accelerated ageing, intellectual disability (ID) and Alzheimer’s disease (AD). The contributions of individual HSA21 gene overdoses to these features remain poorly understood. Methods: iP...

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Bibliographic Details
Main Author: Gough, Gillian
Other Authors: Foo Jia Nee
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2021
Subjects:
Science::Medicine
Online Access:https://hdl.handle.net/10356/153265

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