Mathematical modelling of PLGA degradation using deterministic population balance model
In the recent years there has been an increasing interest in the application of biodegradable polymer for drug delivery systems. The degradation of Poly(lactic-co-glycolic acid) ,PLGA is one such type of polymer that has been the focus of many recent studies. Like most polymers related phenomenon, t...
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| Format: | Final Year Project (FYP) |
| Language: | English |
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2009
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| Online Access: | http://hdl.handle.net/10356/15345 |
| _version_ | 1824454653207642112 |
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| author | Yip, Jason Kong Wai. |
| author2 | Zhao Yang |
| author_facet | Zhao Yang Yip, Jason Kong Wai. |
| author_sort | Yip, Jason Kong Wai. |
| collection | NTU |
| description | In the recent years there has been an increasing interest in the application of biodegradable polymer for drug delivery systems. The degradation of Poly(lactic-co-glycolic acid) ,PLGA is one such type of polymer that has been the focus of many recent studies. Like most polymers related phenomenon, the many probabilistic models describing PLGA hydrolysis has been very limited to a micro scale. This is insufficient or inefficient for use in larger scale research or industrial applications. In order to quantify and describe the various findings mathematically, a model is needed to be able to predict polymer degradation on a macro scale.
This report shall propose and describe a deterministic Population Balancing method using a binary tree model to simulate PLGA hydrolytic degradation. A comparison will be made of the simulated data and the theoretical degradation data. The report shall also show the capability of the model to demonstrate degradation with different initial polymeric factors such as molecular weight. Lastly a method will be proposed to use this binary tree model to simulate more complicate cases of PLGA degradation where diffusion rate is a limiting factor. |
| first_indexed | 2025-02-19T03:25:44Z |
| format | Final Year Project (FYP) |
| id | ntu-10356/15345 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:25:44Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | ntu-10356/153452023-03-04T15:32:06Z Mathematical modelling of PLGA degradation using deterministic population balance model Yip, Jason Kong Wai. Zhao Yang School of Materials Science and Engineering DRNTU::Engineering::Computer science and engineering::Computing methodologies::Simulation and modeling In the recent years there has been an increasing interest in the application of biodegradable polymer for drug delivery systems. The degradation of Poly(lactic-co-glycolic acid) ,PLGA is one such type of polymer that has been the focus of many recent studies. Like most polymers related phenomenon, the many probabilistic models describing PLGA hydrolysis has been very limited to a micro scale. This is insufficient or inefficient for use in larger scale research or industrial applications. In order to quantify and describe the various findings mathematically, a model is needed to be able to predict polymer degradation on a macro scale. This report shall propose and describe a deterministic Population Balancing method using a binary tree model to simulate PLGA hydrolytic degradation. A comparison will be made of the simulated data and the theoretical degradation data. The report shall also show the capability of the model to demonstrate degradation with different initial polymeric factors such as molecular weight. Lastly a method will be proposed to use this binary tree model to simulate more complicate cases of PLGA degradation where diffusion rate is a limiting factor. Bachelor of Engineering (Materials Engineering) 2009-04-27T08:52:35Z 2009-04-27T08:52:35Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/15345 en 38 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Computer science and engineering::Computing methodologies::Simulation and modeling Yip, Jason Kong Wai. Mathematical modelling of PLGA degradation using deterministic population balance model |
| title | Mathematical modelling of PLGA degradation using deterministic population balance model |
| title_full | Mathematical modelling of PLGA degradation using deterministic population balance model |
| title_fullStr | Mathematical modelling of PLGA degradation using deterministic population balance model |
| title_full_unstemmed | Mathematical modelling of PLGA degradation using deterministic population balance model |
| title_short | Mathematical modelling of PLGA degradation using deterministic population balance model |
| title_sort | mathematical modelling of plga degradation using deterministic population balance model |
| topic | DRNTU::Engineering::Computer science and engineering::Computing methodologies::Simulation and modeling |
| url | http://hdl.handle.net/10356/15345 |
| work_keys_str_mv | AT yipjasonkongwai mathematicalmodellingofplgadegradationusingdeterministicpopulationbalancemodel |