Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners
Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with K...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2021
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| Online Access: | https://hdl.handle.net/10356/153866 |
| _version_ | 1824455675293466624 |
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| author | Molton, James S. Lee, I. Russel Bertrand, Denis Ding, Ying Kalimuddin, Shirin Lye, David C. Nagarajan, Niranjan Gan, Yunn-Hwen Archuleta, Sophia |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Molton, James S. Lee, I. Russel Bertrand, Denis Ding, Ying Kalimuddin, Shirin Lye, David C. Nagarajan, Niranjan Gan, Yunn-Hwen Archuleta, Sophia |
| author_sort | Molton, James S. |
| collection | NTU |
| description | Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households.
Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed.
Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool.
Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. |
| first_indexed | 2025-02-19T03:41:58Z |
| format | Journal Article |
| id | ntu-10356/153866 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:41:58Z |
| publishDate | 2021 |
| record_format | dspace |
| spelling | ntu-10356/1538662023-03-05T16:45:38Z Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners Molton, James S. Lee, I. Russel Bertrand, Denis Ding, Ying Kalimuddin, Shirin Lye, David C. Nagarajan, Niranjan Gan, Yunn-Hwen Archuleta, Sophia Lee Kong Chian School of Medicine (LKCMedicine) National University of Singapore National Centre for Infectious Diseases Tan Tock Seng Hospital Science::Medicine Klebsiella Pneumoniae Liver Abscess Objectives: Hypermucoviscous Klebsiella pneumoniae is an emerging cause of community-acquired liver abscess. The aim of this study was to investigate whether hypermucoviscous strains could be shared among households. Methods: The clinical K. pneumoniae isolates from a cohort of 24 patients with Klebsiella liver abscess were genotyped, and the stool metagenomes of the index patients and their cohabiting domestic partners were analyzed. Results: K. pneumoniae was identified in 33% of index patient stools, and one index patient's clinical isolate was identified in their domestic partner's stool. Conclusions: This could represent a transmission event or could represent exposure to a common environmental source. (C) 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. Singapore Infectious Diseases Initiative - National Medical Research Council Published version This work was supported by the Singapore Infectious Diseases Initiative (grant number SIDI/2016/003). 2021-12-16T07:08:11Z 2021-12-16T07:08:11Z 2021 Journal Article Molton, J. S., Lee, I. R., Bertrand, D., Ding, Y., Kalimuddin, S., Lye, D. C., Nagarajan, N., Gan, Y. & Archuleta, S. (2021). Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners. International Journal of Infectious Diseases, 107, 1-4. https://dx.doi.org/10.1016/j.ijid.2021.04.012 1201-9712 https://hdl.handle.net/10356/153866 10.1016/j.ijid.2021.04.012 33862216 2-s2.0-85105269502 107 1 4 en SIDI/2016/0 03 International Journal of Infectious Diseases © 2021 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-ncnd/4.0/). application/pdf |
| spellingShingle | Science::Medicine Klebsiella Pneumoniae Liver Abscess Molton, James S. Lee, I. Russel Bertrand, Denis Ding, Ying Kalimuddin, Shirin Lye, David C. Nagarajan, Niranjan Gan, Yunn-Hwen Archuleta, Sophia Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title_full | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title_fullStr | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title_full_unstemmed | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title_short | Stool metagenome analysis of patients with Klebsiella pneumoniae liver abscess and their domestic partners |
| title_sort | stool metagenome analysis of patients with klebsiella pneumoniae liver abscess and their domestic partners |
| topic | Science::Medicine Klebsiella Pneumoniae Liver Abscess |
| url | https://hdl.handle.net/10356/153866 |
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