A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants
The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either sy...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/153948 |
| _version_ | 1826121996059017216 |
|---|---|
| author | Lay, Christophe Chu, Collins Wenhan Purbojati, Rikky Wenang Acerbi, Enzo Drautz-Moses, Daniela Isabel de Sessions, Paola Florez Jie, Song Ho, Eliza Kok, Yee Jiun Bi, Xuezhi Chen, Shuwen Mak, Shi Ya Chua, Mei Chien Goh, Anne E. N. Chiang, Wen Chin Rao, Rajeshwar Chaithongwongwatthana, Surasith Khemapech, Nipon Chongsrisawat, Voranush Martin, Rocio JULIUS Study Group, Guus Roeselers Ho, Ying Swan Hibberd, Martin L. Schuster, Stephan Christoph Knol, Jan |
| author2 | Singapore Centre for Environmental Life Sciences and Engineering |
| author_facet | Singapore Centre for Environmental Life Sciences and Engineering Lay, Christophe Chu, Collins Wenhan Purbojati, Rikky Wenang Acerbi, Enzo Drautz-Moses, Daniela Isabel de Sessions, Paola Florez Jie, Song Ho, Eliza Kok, Yee Jiun Bi, Xuezhi Chen, Shuwen Mak, Shi Ya Chua, Mei Chien Goh, Anne E. N. Chiang, Wen Chin Rao, Rajeshwar Chaithongwongwatthana, Surasith Khemapech, Nipon Chongsrisawat, Voranush Martin, Rocio JULIUS Study Group, Guus Roeselers Ho, Ying Swan Hibberd, Martin L. Schuster, Stephan Christoph Knol, Jan |
| author_sort | Lay, Christophe |
| collection | NTU |
| description | The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD. |
| first_indexed | 2024-10-01T05:41:16Z |
| format | Journal Article |
| id | ntu-10356/153948 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:41:16Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1539482022-06-11T20:11:26Z A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants Lay, Christophe Chu, Collins Wenhan Purbojati, Rikky Wenang Acerbi, Enzo Drautz-Moses, Daniela Isabel de Sessions, Paola Florez Jie, Song Ho, Eliza Kok, Yee Jiun Bi, Xuezhi Chen, Shuwen Mak, Shi Ya Chua, Mei Chien Goh, Anne E. N. Chiang, Wen Chin Rao, Rajeshwar Chaithongwongwatthana, Surasith Khemapech, Nipon Chongsrisawat, Voranush Martin, Rocio JULIUS Study Group, Guus Roeselers Ho, Ying Swan Hibberd, Martin L. Schuster, Stephan Christoph Knol, Jan Singapore Centre for Environmental Life Sciences and Engineering Engineering::Environmental engineering Microbiome Infant The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD. Agency for Science, Technology and Research (A*STAR) Published version Danone Nutricia Research funded the clinical study and the analyses of the clinical samples using multi-omics. The Genome Institute of Singapore received an industrial alignment fund, IAF111135, from the Agency for Science, Technology and Research (A*STAR) from Singapore to analyse the clinical samples using 16S rRNA sequencing. The Bioprocessing Technology Institute (BTI) thanks the Agency for Science, Technology and Research (A*STAR) for their funding support (IAF project no. 111199) of HYS and BX for omics data analysis. 2022-06-06T05:12:44Z 2022-06-06T05:12:44Z 2021 Journal Article Lay, C., Chu, C. W., Purbojati, R. W., Acerbi, E., Drautz-Moses, D. I., de Sessions, P. F., Jie, S., Ho, E., Kok, Y. J., Bi, X., Chen, S., Mak, S. Y., Chua, M. C., Goh, A. E. N., Chiang, W. C., Rao, R., Chaithongwongwatthana, S., Khemapech, N., Chongsrisawat, V., ...Knol, J. (2021). A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants. BMC Microbiology, 21(1), 191-. https://dx.doi.org/10.1186/s12866-021-02230-1 1471-2180 https://hdl.handle.net/10356/153948 10.1186/s12866-021-02230-1 34172012 2-s2.0-85109041889 1 21 191 en IAF111135 IAF111199 BMC Microbiology © 2021 The Author(s). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. application/pdf |
| spellingShingle | Engineering::Environmental engineering Microbiome Infant Lay, Christophe Chu, Collins Wenhan Purbojati, Rikky Wenang Acerbi, Enzo Drautz-Moses, Daniela Isabel de Sessions, Paola Florez Jie, Song Ho, Eliza Kok, Yee Jiun Bi, Xuezhi Chen, Shuwen Mak, Shi Ya Chua, Mei Chien Goh, Anne E. N. Chiang, Wen Chin Rao, Rajeshwar Chaithongwongwatthana, Surasith Khemapech, Nipon Chongsrisawat, Voranush Martin, Rocio JULIUS Study Group, Guus Roeselers Ho, Ying Swan Hibberd, Martin L. Schuster, Stephan Christoph Knol, Jan A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title | A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title_full | A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title_fullStr | A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title_full_unstemmed | A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title_short | A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants |
| title_sort | synbiotic intervention modulates meta omics signatures of gut redox potential and acidity in elective caesarean born infants |
| topic | Engineering::Environmental engineering Microbiome Infant |
| url | https://hdl.handle.net/10356/153948 |
| work_keys_str_mv | AT laychristophe asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chucollinswenhan asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT purbojatirikkywenang asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT acerbienzo asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT drautzmosesdanielaisabel asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT desessionspaolaflorez asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT jiesong asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hoeliza asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT kokyeejiun asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT bixuezhi asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chenshuwen asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT makshiya asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chuameichien asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT gohanneen asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chiangwenchin asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT raorajeshwar asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chaithongwongwatthanasurasith asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT khemapechnipon asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chongsrisawatvoranush asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT martinrocio asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT juliusstudygroupguusroeselers asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hoyingswan asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hibberdmartinl asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT schusterstephanchristoph asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT knoljan asynbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT laychristophe synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chucollinswenhan synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT purbojatirikkywenang synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT acerbienzo synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT drautzmosesdanielaisabel synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT desessionspaolaflorez synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT jiesong synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hoeliza synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT kokyeejiun synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT bixuezhi synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chenshuwen synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT makshiya synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chuameichien synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT gohanneen synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chiangwenchin synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT raorajeshwar synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chaithongwongwatthanasurasith synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT khemapechnipon synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT chongsrisawatvoranush synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT martinrocio synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT juliusstudygroupguusroeselers synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hoyingswan synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT hibberdmartinl synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT schusterstephanchristoph synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants AT knoljan synbioticinterventionmodulatesmetaomicssignaturesofgutredoxpotentialandacidityinelectivecaesareanborninfants |