Evaluation of host defense peptide (CaD23)-antibiotic interaction and mechanism of action: insights from experimental and molecular dynamics simulations studies

Evaluation of host defense peptide (CaD23)-antibiotic interaction and mechanism of action: insights from experimental and molecular dynamics simulations studies

Background/Aim: Host defense peptides (HDPs) have the potential to provide a novel solution to antimicrobial resistance (AMR) in view of their unique and broad-spectrum antimicrobial activities. We had recently developed a novel hybrid HDP based on LL-37 and human beta-defensin-2, named CaD23, which...

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Bibliographic Details
Main Authors: Ting, Darren Shu Jeng, Li, Jianguo, Verma, Chandra Shekhar, Goh, Eunice T. L., Nubile, Mario, Mastropasqua, Leonardo, Said, Dalia G., Beuerman, Roger W., Lakshminarayanan, Rajamani, Imran Mohammed, Dua, Harminder S.
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2022
Subjects:
Science::Biological sciences
Antimicrobial Peptide
Cathelicidin (LL37)
Online Access:https://hdl.handle.net/10356/154076

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