Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China
Manchu is the third-largest ethnic minority in China and has the largest population size among the Tungusic-speaking groups. However, the genetic origin and admixture history of the Manchu people are far from clear due to the sparse sampling and a limited number of markers genotyped. Here, we provid...
| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/154179 |
| _version_ | 1811680297419276288 |
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| author | Zhang, Xianpeng He, Guanglin Li, Wenhui Wang, Yunfeng Li, Xin Chen, Ying Qu, Quanying Wang, Ying Xi, Huanjiu Wang, Chuan-Chao Wen, Youfeng |
| author2 | School of Humanities |
| author_facet | School of Humanities Zhang, Xianpeng He, Guanglin Li, Wenhui Wang, Yunfeng Li, Xin Chen, Ying Qu, Quanying Wang, Ying Xi, Huanjiu Wang, Chuan-Chao Wen, Youfeng |
| author_sort | Zhang, Xianpeng |
| collection | NTU |
| description | Manchu is the third-largest ethnic minority in China and has the largest population size among the Tungusic-speaking groups. However, the genetic origin and admixture history of the Manchu people are far from clear due to the sparse sampling and a limited number of markers genotyped. Here, we provided the first batch of genome-wide data of genotyping approximate 700,000 single-nucleotide polymorphisms (SNPs) in 93 Manchu individuals collected from northeast China. We merged the newly generated data with data of publicly available modern and ancient East Asians to comprehensively characterize the genetic diversity and fine-scale population structure, as well as explore the genetic origin and admixture history of northern Chinese Manchus. We applied both descriptive methods of ADMIXTURE, fineSTRUCTURE, F ST , TreeMix, identity by decedent (IBD), principal component analysis (PCA), and qualitative f-statistics (f 3, f 4, qpAdm, and qpWave). We found that Liaoning Manchus have a close genetic relationship and significant admixture signal with northern Han Chinese, which is in line with the cluster patterns in the haplotype-based results. Additionally, the qpAdm-based admixture models showed that modern Manchu people were formed as major ancestry related to Yellow River farmers and minor ancestry linked to ancient populations from Amur River Bain, or others. In summary, the northeastern Chinese Manchu people in Liaoning were an exception to the coherent genetic structure of Tungusic-speaking populations, probably due to the large-scale population migrations and genetic admixtures in the past few hundred years. |
| first_indexed | 2024-10-01T03:22:49Z |
| format | Journal Article |
| id | ntu-10356/154179 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:22:49Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1541792023-03-11T20:05:50Z Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China Zhang, Xianpeng He, Guanglin Li, Wenhui Wang, Yunfeng Li, Xin Chen, Ying Qu, Quanying Wang, Ying Xi, Huanjiu Wang, Chuan-Chao Wen, Youfeng School of Humanities Humanities::General East Asia Genetic Admixture Manchu is the third-largest ethnic minority in China and has the largest population size among the Tungusic-speaking groups. However, the genetic origin and admixture history of the Manchu people are far from clear due to the sparse sampling and a limited number of markers genotyped. Here, we provided the first batch of genome-wide data of genotyping approximate 700,000 single-nucleotide polymorphisms (SNPs) in 93 Manchu individuals collected from northeast China. We merged the newly generated data with data of publicly available modern and ancient East Asians to comprehensively characterize the genetic diversity and fine-scale population structure, as well as explore the genetic origin and admixture history of northern Chinese Manchus. We applied both descriptive methods of ADMIXTURE, fineSTRUCTURE, F ST , TreeMix, identity by decedent (IBD), principal component analysis (PCA), and qualitative f-statistics (f 3, f 4, qpAdm, and qpWave). We found that Liaoning Manchus have a close genetic relationship and significant admixture signal with northern Han Chinese, which is in line with the cluster patterns in the haplotype-based results. Additionally, the qpAdm-based admixture models showed that modern Manchu people were formed as major ancestry related to Yellow River farmers and minor ancestry linked to ancient populations from Amur River Bain, or others. In summary, the northeastern Chinese Manchu people in Liaoning were an exception to the coherent genetic structure of Tungusic-speaking populations, probably due to the large-scale population migrations and genetic admixtures in the past few hundred years. Published version This study was supported by grants from the National Natural Science Foundation of China (No. 31571233), the scientific research project from the Education Department of Liaoning Province (No. JYTJCZR2020074), the Nanqiang Outstanding Young Talents Program of Xiamen University (X2123302), the Fundamental Research Funds for the Central Universities (ZK1144), the Major Project of the National Social Science Foundation of China (20&ZD248), and European Research Council (ERC) grant (ERC-2019-ADG-883700-TRAM). 2022-06-08T08:23:52Z 2022-06-08T08:23:52Z 2021 Journal Article Zhang, X., He, G., Li, W., Wang, Y., Li, X., Chen, Y., Qu, Q., Wang, Y., Xi, H., Wang, C. & Wen, Y. (2021). Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China. Frontiers in Genetics, 12, 754492-. https://dx.doi.org/10.3389/fgene.2021.754492 1664-8021 https://hdl.handle.net/10356/154179 10.3389/fgene.2021.754492 34659368 2-s2.0-85117152394 12 754492 en Frontiers in Genetics © 2021 Zhang, He, Li, Wang, Li, Chen, Qu, Wang, Xi, Wang and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. application/pdf |
| spellingShingle | Humanities::General East Asia Genetic Admixture Zhang, Xianpeng He, Guanglin Li, Wenhui Wang, Yunfeng Li, Xin Chen, Ying Qu, Quanying Wang, Ying Xi, Huanjiu Wang, Chuan-Chao Wen, Youfeng Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title | Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title_full | Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title_fullStr | Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title_full_unstemmed | Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title_short | Genomic insight into the population admixture history of Tungusic-speaking Manchu people in Northeast China |
| title_sort | genomic insight into the population admixture history of tungusic speaking manchu people in northeast china |
| topic | Humanities::General East Asia Genetic Admixture |
| url | https://hdl.handle.net/10356/154179 |
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