Transdermal therapy for skin and metabolic diseases
Skin is the readily accessible window for a wide range of theranostic purposes. Transdermal drug delivery across skin barrier-stratum corneum could be an effective method for treating numerous diseases. In this thesis, transdermal therapies based on polymeric microneedle (MN) patch and injectable th...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2021
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| Online Access: | https://hdl.handle.net/10356/154386 |
| _version_ | 1811692759070801920 |
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| author | Zan, Ping |
| author2 | Chen Peng |
| author_facet | Chen Peng Zan, Ping |
| author_sort | Zan, Ping |
| collection | NTU |
| description | Skin is the readily accessible window for a wide range of theranostic purposes. Transdermal drug delivery across skin barrier-stratum corneum could be an effective method for treating numerous diseases. In this thesis, transdermal therapies based on polymeric microneedle (MN) patch and injectable thermo-responsive hydrogel were investigated for their therapeutic performance on skin and metabolic diseases.
Firstly, a new transdermal strategy using an antimicrobial MN patch is invented for treating deep cutaneous fungal infection, which is difficult to be treated by conventional topical formulations or oral intake of antifungal agents due to low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. This MN patch is not only able to overcome the skin barrier, but also possesses antimicrobial property immune to drug resistance and provides sustained drug release because MN itself is made of biocompatible and biodegradable chitosan–polyethylenimine copolymer. Using a fungal infection mouse model, it is demonstrated that this MN patch incorporated with antifungal agent amphotericin B offers outstanding treatment effectiveness, which is credited to the high bioavailability of therapeutics and sustained synergistic actions from the antifungal polymer and drug. |
| first_indexed | 2024-10-01T06:40:53Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/154386 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:40:53Z |
| publishDate | 2021 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1543862022-01-05T09:23:40Z Transdermal therapy for skin and metabolic diseases Zan, Ping Chen Peng School of Chemical and Biomedical Engineering ChenPeng@ntu.edu.sg Engineering::Bioengineering Skin is the readily accessible window for a wide range of theranostic purposes. Transdermal drug delivery across skin barrier-stratum corneum could be an effective method for treating numerous diseases. In this thesis, transdermal therapies based on polymeric microneedle (MN) patch and injectable thermo-responsive hydrogel were investigated for their therapeutic performance on skin and metabolic diseases. Firstly, a new transdermal strategy using an antimicrobial MN patch is invented for treating deep cutaneous fungal infection, which is difficult to be treated by conventional topical formulations or oral intake of antifungal agents due to low drug bioavailability to the infection site, lack of sustained therapeutic effect, and development of drug resistance. This MN patch is not only able to overcome the skin barrier, but also possesses antimicrobial property immune to drug resistance and provides sustained drug release because MN itself is made of biocompatible and biodegradable chitosan–polyethylenimine copolymer. Using a fungal infection mouse model, it is demonstrated that this MN patch incorporated with antifungal agent amphotericin B offers outstanding treatment effectiveness, which is credited to the high bioavailability of therapeutics and sustained synergistic actions from the antifungal polymer and drug. Doctor of Philosophy 2021-12-23T11:53:59Z 2021-12-23T11:53:59Z 2021 Thesis-Doctor of Philosophy Zan, P. (2021). Transdermal therapy for skin and metabolic diseases. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/154386 https://hdl.handle.net/10356/154386 10.32657/10356/154386 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Engineering::Bioengineering Zan, Ping Transdermal therapy for skin and metabolic diseases |
| title | Transdermal therapy for skin and metabolic diseases |
| title_full | Transdermal therapy for skin and metabolic diseases |
| title_fullStr | Transdermal therapy for skin and metabolic diseases |
| title_full_unstemmed | Transdermal therapy for skin and metabolic diseases |
| title_short | Transdermal therapy for skin and metabolic diseases |
| title_sort | transdermal therapy for skin and metabolic diseases |
| topic | Engineering::Bioengineering |
| url | https://hdl.handle.net/10356/154386 |
| work_keys_str_mv | AT zanping transdermaltherapyforskinandmetabolicdiseases |