Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment
Osteoarthritis (OA) is one of the most common musculoskeletal disorders worldwide. Oxidative stress initiated by excessive free radicals such as reactive oxygen species (ROS) is a leading cause of cartilage degradation and OA. However, conventional injection or oral intake of antioxidants usually ca...
| Main Authors: | , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/154796 |
| _version_ | 1826129141405057024 |
|---|---|
| author | Liang, Ruiming Zhao, Jinmin Li, Bo Cai, Peian Loh, Xian Jun Xu, Chuanhui Chen, Peng Kai, Dan Zheng, Li |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Liang, Ruiming Zhao, Jinmin Li, Bo Cai, Peian Loh, Xian Jun Xu, Chuanhui Chen, Peng Kai, Dan Zheng, Li |
| author_sort | Liang, Ruiming |
| collection | NTU |
| description | Osteoarthritis (OA) is one of the most common musculoskeletal disorders worldwide. Oxidative stress initiated by excessive free radicals such as reactive oxygen species (ROS) is a leading cause of cartilage degradation and OA. However, conventional injection or oral intake of antioxidants usually cannot provide effective treatment due to rapid clearance and degradation or low bioavailability. Here, a new strategy is proposed based on nanofibers made of poly (ε-caprolactone) (PCL) and PCL-grafted lignin (PCL-g-lignin) copolymer. Lignin offers intrinsic antioxidant activity while PCL tailors the mechanical properties. Electrospun PCL-lignin nanofibers show excellent antioxidant activity, low cytotoxicity and excellent anti-inflammatory effects as demonstrated using both H2O2-stimulated human chondrocytes and an OA rabbit model. PCL-lignin nanofibers inhibit ROS generation and activate antioxidant enzymes through autophagic mechanism. Arthroscopic implantation of nanofibrous membrane of PCL-lignin is effective to OA therapy because it is biocompatible, biodegradable and able to provide sustained antioxidant activity. |
| first_indexed | 2024-10-01T07:35:51Z |
| format | Journal Article |
| id | ntu-10356/154796 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:35:51Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1547962022-01-10T01:28:47Z Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment Liang, Ruiming Zhao, Jinmin Li, Bo Cai, Peian Loh, Xian Jun Xu, Chuanhui Chen, Peng Kai, Dan Zheng, Li School of Chemical and Biomedical Engineering Engineering::Chemical engineering Lignin Nanofiber Osteoarthritis (OA) is one of the most common musculoskeletal disorders worldwide. Oxidative stress initiated by excessive free radicals such as reactive oxygen species (ROS) is a leading cause of cartilage degradation and OA. However, conventional injection or oral intake of antioxidants usually cannot provide effective treatment due to rapid clearance and degradation or low bioavailability. Here, a new strategy is proposed based on nanofibers made of poly (ε-caprolactone) (PCL) and PCL-grafted lignin (PCL-g-lignin) copolymer. Lignin offers intrinsic antioxidant activity while PCL tailors the mechanical properties. Electrospun PCL-lignin nanofibers show excellent antioxidant activity, low cytotoxicity and excellent anti-inflammatory effects as demonstrated using both H2O2-stimulated human chondrocytes and an OA rabbit model. PCL-lignin nanofibers inhibit ROS generation and activate antioxidant enzymes through autophagic mechanism. Arthroscopic implantation of nanofibrous membrane of PCL-lignin is effective to OA therapy because it is biocompatible, biodegradable and able to provide sustained antioxidant activity. Agency for Science, Technology and Research (A*STAR) This study was financially supported by National key R&D program of China (2018YFC1105900), the Guangxi Science and Technology Base and Talent Special Project (Grant No. GuikeAD17129012), and the local Science and Technology Development Project leading by the central government (the three-D printing and digital medical platform, Grant No. GuikeZY18164004), High level innovation teams and outstanding scholars in Guangxi Universities (The third batch). The authors gratefully acknowledge the financial support from the Institute of Materials Research and Engineering (IMRE) under the Agency of Science, Technology and Research (A*STAR). 2022-01-10T01:28:47Z 2022-01-10T01:28:47Z 2020 Journal Article Liang, R., Zhao, J., Li, B., Cai, P., Loh, X. J., Xu, C., Chen, P., Kai, D. & Zheng, L. (2020). Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment. Biomaterials, 230, 119601-. https://dx.doi.org/10.1016/j.biomaterials.2019.119601 0142-9612 https://hdl.handle.net/10356/154796 10.1016/j.biomaterials.2019.119601 31711715 2-s2.0-85075482110 230 119601 en Biomaterials © 2019 Elsevier Ltd. All rights reserved. |
| spellingShingle | Engineering::Chemical engineering Lignin Nanofiber Liang, Ruiming Zhao, Jinmin Li, Bo Cai, Peian Loh, Xian Jun Xu, Chuanhui Chen, Peng Kai, Dan Zheng, Li Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title | Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title_full | Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title_fullStr | Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title_full_unstemmed | Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title_short | Implantable and degradable antioxidant poly(ε-caprolactone)-lignin nanofiber membrane for effective osteoarthritis treatment |
| title_sort | implantable and degradable antioxidant poly ε caprolactone lignin nanofiber membrane for effective osteoarthritis treatment |
| topic | Engineering::Chemical engineering Lignin Nanofiber |
| url | https://hdl.handle.net/10356/154796 |
| work_keys_str_mv | AT liangruiming implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT zhaojinmin implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT libo implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT caipeian implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT lohxianjun implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT xuchuanhui implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT chenpeng implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT kaidan implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment AT zhengli implantableanddegradableantioxidantpolyecaprolactoneligninnanofibermembraneforeffectiveosteoarthritistreatment |