Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution
In biological systems, biomolecules such as amino acids play important roles as building blocks of proteins and precursors to several neurotransmitters. The amino acids and their radicals are involved in several biological processes, and they are therefore of interest. The development of ultrashort...
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| Format: | Thesis-Doctor of Philosophy |
| Language: | English |
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Nanyang Technological University
2022
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| Online Access: | https://hdl.handle.net/10356/154805 |
| _version_ | 1811697717682896896 |
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| author | Muhammad Shafiq Mohd Yusof |
| author2 | Loh Zhi Heng |
| author_facet | Loh Zhi Heng Muhammad Shafiq Mohd Yusof |
| author_sort | Muhammad Shafiq Mohd Yusof |
| collection | NTU |
| description | In biological systems, biomolecules such as amino acids play important roles as building blocks of proteins and precursors to several neurotransmitters. The amino acids and their radicals are involved in several biological processes, and they are therefore of interest. The development of ultrashort pulses allows scientists to study and elucidate many of these ultrafast processes. In this work, I will present the ultrafast dynamics of photoionized or photodetached biomolecules in aqueous solution by utilizing sub-6 fs laser pulses in transient absorption pump-probe spectroscopy. I will present the ultrafast vibrational wave packet dynamics of photodetached aqueous tyrosinate dianion, tryptophan anion and phenylalaninate anion. In addition, the study on the photodetached phenylalaninate anion aims to understand the photodissociation behavior of the phenylalanine radical upon photodetached. Moreover, the study on ionized phenol, the sidechain of tyrosine, investigates the ultrafast proton transfer dynamics of the phenol radical cation in aqueous solution. Our experimental results are complemented with density functional theory (DFT) calculations. |
| first_indexed | 2024-10-01T07:59:42Z |
| format | Thesis-Doctor of Philosophy |
| id | ntu-10356/154805 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:59:42Z |
| publishDate | 2022 |
| publisher | Nanyang Technological University |
| record_format | dspace |
| spelling | ntu-10356/1548052023-02-28T23:56:38Z Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution Muhammad Shafiq Mohd Yusof Loh Zhi Heng School of Physical and Mathematical Sciences zhiheng@ntu.edu.sg Science::Chemistry::Physical chemistry In biological systems, biomolecules such as amino acids play important roles as building blocks of proteins and precursors to several neurotransmitters. The amino acids and their radicals are involved in several biological processes, and they are therefore of interest. The development of ultrashort pulses allows scientists to study and elucidate many of these ultrafast processes. In this work, I will present the ultrafast dynamics of photoionized or photodetached biomolecules in aqueous solution by utilizing sub-6 fs laser pulses in transient absorption pump-probe spectroscopy. I will present the ultrafast vibrational wave packet dynamics of photodetached aqueous tyrosinate dianion, tryptophan anion and phenylalaninate anion. In addition, the study on the photodetached phenylalaninate anion aims to understand the photodissociation behavior of the phenylalanine radical upon photodetached. Moreover, the study on ionized phenol, the sidechain of tyrosine, investigates the ultrafast proton transfer dynamics of the phenol radical cation in aqueous solution. Our experimental results are complemented with density functional theory (DFT) calculations. Doctor of Philosophy 2022-01-10T05:16:18Z 2022-01-10T05:16:18Z 2021 Thesis-Doctor of Philosophy Muhammad Shafiq Mohd Yusof (2021). Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/154805 https://hdl.handle.net/10356/154805 10.32657/10356/154805 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
| spellingShingle | Science::Chemistry::Physical chemistry Muhammad Shafiq Mohd Yusof Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title | Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title_full | Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title_fullStr | Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title_full_unstemmed | Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title_short | Direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| title_sort | direct observation of the ultrafast dynamics of ionized biomolecules in aqueous solution |
| topic | Science::Chemistry::Physical chemistry |
| url | https://hdl.handle.net/10356/154805 |
| work_keys_str_mv | AT muhammadshafiqmohdyusof directobservationoftheultrafastdynamicsofionizedbiomoleculesinaqueoussolution |