Iterative addition of carbon nucleophiles toN,N-dialkyl carboxamides for synthesis of α-tertiary amines

Iterative addition of carbon nucleophiles toN,N-dialkyl carboxamides for synthesis of α-tertiary amines

A protocol for the synthesis of α-tertiary amines was developed by iterative addition of carbon nucleophiles toN,N-dialkyl carboxamides. Nucleophilic 1,2-addition of organolithium reagents to carboxamides forms anionic tetrahedral carbinolamine (hemiaminal) intermediates, which are subsequently trea...

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Detalhes bibliográficos
Principais autores:	Chen, Jiahua, Lim, Jun Wei, Ong, Derek Yiren, Chiba, Shunsuke
Outros Autores:	School of Physical and Mathematical Sciences
Formato:	Journal Article
Idioma:	English
Publicado em:	2022
Assuntos:	Science::Chemistry Carbon Nucleophiles
Acesso em linha:	https://hdl.handle.net/10356/154825

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