Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings
Oral delivery is one of the facile methods for the administration of active ingredients (AI) like nutraceuticals and drugs. However, its intrinsic disadvantages include poor absorption and bioavailability, degradation of the AI during transit through the gastro-intestinal tract (GIT), and a lack of...
| Main Authors: | , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/155037 |
| _version_ | 1824453963211079680 |
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| author | Sampathkumar, Kaarunya Loo, Joachim Say Chye |
| author2 | School of Materials Science and Engineering |
| author_facet | School of Materials Science and Engineering Sampathkumar, Kaarunya Loo, Joachim Say Chye |
| author_sort | Sampathkumar, Kaarunya |
| collection | NTU |
| description | Oral delivery is one of the facile methods for the administration of active ingredients (AI) like nutraceuticals and drugs. However, its intrinsic disadvantages include poor absorption and bioavailability, degradation of the AI during transit through the gastro-intestinal tract (GIT), and a lack of action specificity. Hence, a delivery system for targeted gastro-intestinal delivery of AI using polysaccharide-based polymers, that are generally recognized as safe (GRAS) and approved for use as a direct food additive, is proposed. In this regard, muco-adhesive chitosan nanoparticles that could adhere to the mucosa of the GIT are fabricated, and encapsulated with AI. These particles are subsequently coated with polysaccharides that have different enzymatic susceptibilities, to allow for specific degradation in the small or large intestines. It is observed that the polysaccharide coating efficiently retarded the non-specific release of the encapsulated agent until it is exposed to its intended environment of release. The cytotoxicity and uptake of chitosan nanoparticles is further evaluated on Caco2 cells. In conclusion, these polysaccharide-coated nanoparticles can potentially be targeted to different organs in the GIT and to be taken up by the enterocytes for improved oral bioavailability. |
| first_indexed | 2025-02-19T03:14:46Z |
| format | Journal Article |
| id | ntu-10356/155037 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:14:46Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1550372024-10-10T01:05:11Z Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings Sampathkumar, Kaarunya Loo, Joachim Say Chye School of Materials Science and Engineering Singapore Centre for Environmental Life Sciences and Engineering (SCELSE) Engineering::Bioengineering Bioavailability Chitosan Delivery Systems Encapsulation Nanoaprticles Oral delivery is one of the facile methods for the administration of active ingredients (AI) like nutraceuticals and drugs. However, its intrinsic disadvantages include poor absorption and bioavailability, degradation of the AI during transit through the gastro-intestinal tract (GIT), and a lack of action specificity. Hence, a delivery system for targeted gastro-intestinal delivery of AI using polysaccharide-based polymers, that are generally recognized as safe (GRAS) and approved for use as a direct food additive, is proposed. In this regard, muco-adhesive chitosan nanoparticles that could adhere to the mucosa of the GIT are fabricated, and encapsulated with AI. These particles are subsequently coated with polysaccharides that have different enzymatic susceptibilities, to allow for specific degradation in the small or large intestines. It is observed that the polysaccharide coating efficiently retarded the non-specific release of the encapsulated agent until it is exposed to its intended environment of release. The cytotoxicity and uptake of chitosan nanoparticles is further evaluated on Caco2 cells. In conclusion, these polysaccharide-coated nanoparticles can potentially be targeted to different organs in the GIT and to be taken up by the enterocytes for improved oral bioavailability. Ministry of Education (MOE) Accepted version The authors would like to acknowledge the financial support from the Singapore Centre on Environmental Life Sciences Engineering (SCELSE) (M4330001.C70), the School of Materials Science and Engineering (M020070110), the NTU-National Healthcare Group (NTU-NHG) grant (ARG/14012), the Ministry of Education Tier 1 grant (RG11/16), and the NTU-HSPH 17002 grant. 2022-02-04T04:54:19Z 2022-02-04T04:54:19Z 2018 Journal Article Sampathkumar, K. & Loo, J. S. C. (2018). Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings. Macromolecular Bioscience, 18(4), 1700363-. https://dx.doi.org/10.1002/mabi.201700363 1616-5187 https://hdl.handle.net/10356/155037 10.1002/mabi.201700363 4 18 1700363 en M4330001.C70 M020070110 ARG/14012 RG11/16) NTU-HSPH 17002 Macromolecular Bioscience This is the peer reviewed version of the following article: Sampathkumar, K. & Loo, J. S. C. (2018). Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings. Macromolecular Bioscience, 18(4), 1700363-, which has been published in final form at https://doi.org/10.1002/mabi.201700363. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. application/pdf |
| spellingShingle | Engineering::Bioengineering Bioavailability Chitosan Delivery Systems Encapsulation Nanoaprticles Sampathkumar, Kaarunya Loo, Joachim Say Chye Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title | Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title_full | Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title_fullStr | Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title_full_unstemmed | Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title_short | Targeted gastrointestinal delivery of nutraceuticals with polysaccharide-based coatings |
| title_sort | targeted gastrointestinal delivery of nutraceuticals with polysaccharide based coatings |
| topic | Engineering::Bioengineering Bioavailability Chitosan Delivery Systems Encapsulation Nanoaprticles |
| url | https://hdl.handle.net/10356/155037 |
| work_keys_str_mv | AT sampathkumarkaarunya targetedgastrointestinaldeliveryofnutraceuticalswithpolysaccharidebasedcoatings AT loojoachimsaychye targetedgastrointestinaldeliveryofnutraceuticalswithpolysaccharidebasedcoatings |