Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines
A 1,2-dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P- and C-chiral 1,...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2022
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| Online Access: | https://hdl.handle.net/10356/155238 |
| _version_ | 1826116972305186816 |
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| author | Teo, Ronald Hong Xiang Chen, Jeremy Houguang Li, Yongxin Pullarkat, Sumod A. Leung, Pak-Hing |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Teo, Ronald Hong Xiang Chen, Jeremy Houguang Li, Yongxin Pullarkat, Sumod A. Leung, Pak-Hing |
| author_sort | Teo, Ronald Hong Xiang |
| collection | NTU |
| description | A 1,2-dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P- and C-chiral 1,2-diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo-integrity. (Figure presented.). |
| first_indexed | 2024-10-01T04:20:09Z |
| format | Journal Article |
| id | ntu-10356/155238 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:20:09Z |
| publishDate | 2022 |
| record_format | dspace |
| spelling | ntu-10356/1552382022-03-02T07:05:39Z Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines Teo, Ronald Hong Xiang Chen, Jeremy Houguang Li, Yongxin Pullarkat, Sumod A. Leung, Pak-Hing School of Physical and Mathematical Sciences Science::Chemistry Asymmetric Catalysi Chirality A 1,2-dihydrophosphination of bis(phenylphosphino)ethane with a wide range of activated olefins was achieved in a catalytic manner with enantiomeric and diastereomeric excess of up to >99% and 44% respectively. The protocol can be extended to selected substrates leading to free P- and C-chiral 1,2-diphosphines. The synthesized ligands can also undergo direct complexation onto palladium affording complexes with complete retention of stereo-integrity. (Figure presented.). Ministry of Education (MOE) Nanyang Technological University This work was supported by the Ministry of Education Academic Research Fund (AcRF-RG10/19-(S)).We are also grateful to Nanyang Technological University for Ph.D. scholarship to Teo R. H. X 2022-03-02T07:05:39Z 2022-03-02T07:05:39Z 2020 Journal Article Teo, R. H. X., Chen, J. H., Li, Y., Pullarkat, S. A. & Leung, P. (2020). Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines. Advanced Synthesis and Catalysis, 362(12), 2373-2378. https://dx.doi.org/10.1002/adsc.202000131 1615-4150 https://hdl.handle.net/10356/155238 10.1002/adsc.202000131 2-s2.0-85084141874 12 362 2373 2378 en AcRF-RG10/19-(S) Advanced Synthesis and Catalysis © 2020 Wiley-VCHVerlag GmbH& Co. KGaA,Weinheim. All rights reserved. |
| spellingShingle | Science::Chemistry Asymmetric Catalysi Chirality Teo, Ronald Hong Xiang Chen, Jeremy Houguang Li, Yongxin Pullarkat, Sumod A. Leung, Pak-Hing Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title | Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title_full | Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title_fullStr | Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title_full_unstemmed | Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title_short | Asymmetric catalytic 1,2-dihydrophosphination of secondary 1,2-diphosphines - direct access to free P*- and P*,C*-diphosphines |
| title_sort | asymmetric catalytic 1 2 dihydrophosphination of secondary 1 2 diphosphines direct access to free p and p c diphosphines |
| topic | Science::Chemistry Asymmetric Catalysi Chirality |
| url | https://hdl.handle.net/10356/155238 |
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